BMY 7378 dihydrochloride
BMY 7378 dihydrochloride structure
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Common Name | BMY 7378 dihydrochloride | ||
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| CAS Number | 21102-95-4 | Molecular Weight | 458.422 | |
| Density | N/A | Boiling Point | 585.6ºC at 760 mmHg | |
| Molecular Formula | C22H33Cl2N3O3 | Melting Point | 196.5-198.5 °C | |
| MSDS | Chinese USA | Flash Point | 307.9ºC | |
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The Alpha-1D Is the Predominant Alpha-1-Adrenergic Receptor Subtype in Human Epicardial Coronary Arteries
J. Am. Coll. Cardiol. 54 , 1137-45, (2009) Objectives The goal was to identify alpha-1-adrenergic receptor (AR) subtypes in human coronary arteries. |
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Further investigation of the in vivo pharmacological properties of the putative 5-HT1A antagonist, BMY 7378.
Eur. J. Pharmacol. 176 , 331, (1990) The present study examined the actions of the putative 5-HT1A antagonist BMY 7378 on central pre- and postsynaptic 5-HT1A function in the rat in vivo. Unlike the direct acting 5-HT1A agonist 8-hydroxy-2-(di-n-pro-pylamino)tetralin (8-OH-DPAT), BMY 7378 (0.25-... |
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Novel benzodioxopiperazines acting as antagonists at postsynaptic 5-HT1A receptors and as agonists at 5-HT1A autoreceptors: a comparative pharmacological characterization with proposed 5-HT1A antagonists.
J. Pharmacol. Exp. Ther. 268 , 337-352, (1994) The novel benzodioxopiperazines [4-(benzodioxan-5-yl)1-[2- (benzocyclobutane-1-yl)ethyl]piperazine] (S 14489), [4-(benzodioxan-5-yl)1-(indan-2-yl)piperazine)] (S 15535) and [4-(benzodioxan-5-yl)1-[2(indan-1-yl)ethyl]piperazine (S15931) competitively displaced... |
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BMY 7378, a buspirone analog with high affinity, selectivity and low intrinsic activity at the 5-HT1A receptor in rat and guinea pig hippocampal membranes.
Eur. J. Pharmacol. 137 , 293, (1987)
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Is alpha1D-adrenoceptor protein detectable in rat tissues?
Naunyn Schmiedebergs Arch. Pharmacol. 355 , 438-446, (1997) We have used the alpha1D-adrenoceptor selective antagonist, BMY 7378, the alpha1D-selective agonists, adrenaline and phenylephrine, the alpha1A-selective antagonists, (+)-niguldipine, SB 216469 and WB4101, and the non-subtype-selective alpha1-adrenoceptor ant... |
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Buspirone functionally discriminates tissues endowed with alpha1-adrenoceptor subtypes A, B, D and L.
Eur. J. Pharmacol. 378 , 69-83, (1999) The affinity for functional alpha1-adrenoceptor subtypes of buspirone in comparison with its close structural analogs and selective alpha1D-adrenoceptor antagonists, BMY 7378 (8-[2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl]-8-azaspiro[4.5]dec ane-7,9-dione) an... |