H-β-Ala-Phe-OH

H-β-Ala-Phe-OH Structure
H-β-Ala-Phe-OH structure
Common Name H-β-Ala-Phe-OH
CAS Number 17136-28-6 Molecular Weight 236.26700
Density 1.224g/cm3 Boiling Point 506.8ºC at 760mmHg
Molecular Formula C12H16N2O3 Melting Point N/A
MSDS N/A Flash Point 260.3ºC

Estimation of the pH-independent binding constants of alanylphenylalanine and leucylphenylalanine stereoisomers with beta-cyclodextrin in the presence of urea.

Electrophoresis 20(1) , 171-9, (1999)

The separation of stereoisomers, particularly enantiomers, is important when their physiological activity differs. We have resolved the four stereoisomers each of alanylphenylalanine (Ala-Phe) and of leucylphenylalanine (Leu-Phe) by capillary electrophoresis ...

Alkali metal complexes of the dipeptides PheAla and AlaPhe: IRMPD spectroscopy.

ChemPhysChem 9 , 579-589, (2008)

Complexes of PheAla and AlaPhe with alkali metal ions Na(+) and K(+) are generated by electrospray ionization, isolated in the Fourier-transform ion cyclotron resonance (FT-ICR) ion trapping mass spectrometer, and investigated by infrared multiple-photon diss...

Single-conformation ultraviolet and infrared spectroscopy of model synthetic foldamers: beta-peptides Ac-beta3-hPhe-beta3-hAla-NHMe and Ac-beta3-hAla-beta3-hPhe-NHMe.

J. Am. Chem. Soc. 130(14) , 4795-807, (2008)

The conformational preferences and infrared and ultraviolet spectral signatures of two model beta-peptides, Ac-beta3-hPhe-beta3-hAla-NHMe (1) and Ac-beta3-hAla-beta3-hPhe-NHMe (2), have been explored under jet-cooled, isolated-molecule conditions. The mass-re...

Simultaneous determination of Angiotensin I-converting enzyme inhibitory peptides in tryptic casein hydrolysate by high-performance liquid chromatography combined with a replicate heart-cut column-switching technique.

J. Agric. Food Chem. 55(21) , 8367-71, (2007)

A replicate heart-cut column-switching HPLC method combined with two switching valves was newly developed for the simultaneous determination of three antihypertensive peptides (Ala-Phe, Tyr-Pro, and Trp-Tyr) in tryptic casein hydrolysate in one run-in assay. ...

Computed and experimental chemical shift parameters for rigid and flexible YAF peptides in the solid state.

J. Phys. Chem. B 116(6) , 1974-83, (2012)

DFT methods were employed to compute the (13)C NMR chemical shift tensor (CST) parameters for crystals of YAF peptides (Tyr-Ala-Phe) with different stereochemistry for the Ala residue. Tyr-D-Ala-Phe 1 crystallizes in the C2 space group while Tyr-L-Ala-Phe cry...

Chiral separation based on ligand-exchange capillary electrophoresis using a copper(II)-L-ornithine ternary complex as selector.

Electrophoresis 26(4-5) , 1007-12, (2005)

A ligand-exchange capillary electrophoresis was explored, with L-ornithine as the ligand and copper(II) as the central ion. Its applicability was demonstrated with underivatized and dansyl amino acids, a dipeptide, and drugs with amino alcohol structure. The ...

Structural and enzymatic characterization of BacD, an L-amino acid dipeptide ligase from Bacillus subtilis.

Protein Sci. 21(5) , 707-16, (2012)

BacD is an ATP-dependent dipeptide ligase responsible for the biosynthesis of L-alanyl-L-anticapsin, a precursor of an antibiotic produced by Bacillus spp. In contrast to the well-studied and phylogenetically related D-alanine: D-alanine ligase (Ddl), BacD sy...

Structure-based design of residue 1 analogs of the direct thrombin inhibitor pentapeptide FM 19.

Chem. Biol. Drug Des. 75(1) , 35-9, (2010)

Myocardial ischemia and other acute coronary syndromes are leading causes of death worldwide, and often result from a thrombus that blocks an atherosclerotic coronary artery. A key enzyme in thrombus formation is the serine protease thrombin, which is respons...

Spectrophotometric determination of peptide transport with chromogenic peptide mimetics.

Anal. Biochem. 367(2) , 167-72, (2007)

A spectrophotometric assay to determine peptide transport has been developed. Using two chromogenic peptide mimetics, L-phenylalanyl-L-2-sulfanilylglycine (PSG) and L-phenylalanyl-L-3-thiaphenylalanine (PSP), the peptide transport patterns in individual cell ...

Molecular cloning and co-expression of Thermoplasma volcanium proteasome subunit genes.

Protein Expr. Purif. 73(2) , 223-30, (2010)

In this study we describe, the construction of a co-expression vector allowing simultaneous production of Thermoplasma volcanium 20S proteasome alpha- and beta-subunits in Escherichia coli. This heterologous expression system provided high level production of...