Monostearin

Monostearin Structure
Monostearin structure
Common Name Monostearin
CAS Number 123-94-4 Molecular Weight 358.556
Density 1.0±0.1 g/cm3 Boiling Point 476.9±25.0 °C at 760 mmHg
Molecular Formula C21H42O4 Melting Point 78-81ºC
MSDS Chinese USA Flash Point 151.9±16.7 °C

The influence of surface charge and photo-reactivity on skin-permeation enhancer property of nano-TiO₂ in ex vivo pig skin model under indoor light.

Int. J. Pharm. 467(1-2) , 90-9, (2014)

Several topical products contain nanometric TiO2 (nano-TiO2), which is a useful and safe component that absorbs UV light and does not cross skin barrier. However, nano-TiO2 may impregnate the first layer of the skin (stratum corneum, SC) and generate free rad...

Development of a protective dermal drug delivery system for therapeutic DNAzymes.

Int. J. Pharm. 479(1) , 150-8, (2015)

RNA-cleaving DNAzymes are a potential novel class of nucleic acid-based active pharmaceutical ingredients (API). However, developing an appropriate drug delivery system (DDS) that achieves high bioavailability is challenging. Especially in a dermal applicatio...

An oil-soluble extract of Rubus idaeus cells enhances hydration and water homeostasis in skin cells.

Int. J. Cosmet. Sci. 37 , 588-94, (2015)

Raspberry plants, belonging to the species of Rubus idaeus, are known for their excellent therapeutic properties as they are particularly rich in compounds with strong antioxidant activity, which promote health and well-being of human cells. Besides their hig...

Adenosine conjugated lipidic nanoparticles for enhanced tumor targeting.

Int. J. Pharm. 486 , 287-96, (2015)

Delivering chemotherapeutics by nanoparticles into tumor is impeded majorly by two factors: nonspecific targeting and inefficient penetration. Targeted delivery of anti-cancer agents solely to tumor cells introduces a smart strategy because it enhances the th...

In vivo evaluation of porous silicon and porous silicon solid lipid nanocomposites for passive targeting and imaging.

Mol. Pharm. 11(8) , 2876-86, (2014)

The use of nanoparticle carriers for the sustained release of cytotoxic drugs in cancer therapy can result in fewer adverse effects and can thus be of great benefit for the patient. Recently, a novel nanocomposite, prepared by the encapsulation of THCPSi nano...

In-line spatial filtering velocimetry for particle size and film thickness determination in fluidized-bed pellet coating processes.

Eur. J. Pharm. Biopharm. 88(3) , 931-8, (2015)

A spatial filtering velocimetry (SFV) probe was applied to monitor the increase in particle size during pellet Wurster coating processes in-line. Accuracy of the in-line obtained pellet sizes was proven by at-line performed digital image analysis (DIA). Regar...

Acid sphingomyelinase activity is regulated by membrane lipids and facilitates cholesterol transfer by NPC2.

J. Lipid Res. 55(12) , 2606-19, (2014)

During endocytosis, membrane components move to intraluminal vesicles of the endolysosomal compartment for digestion. At the late endosomes, cholesterol is sorted out mainly by two sterol-binding proteins, Niemann-Pick protein type C (NPC)1 and NPC2. To study...

LC-APCI-MS/MS Quantification and Topical Bioavailability of Chloroacetamide in Rats.

J. Chromatogr. Sci. 53 , 1100-6, (2015)

Chloroacetamide (CAA) is a preservative used in various cosmetic, personal care and household products. Due to the hazard potential for allergic reaction and reproductive toxicity, CAA is being considered a high priority for screening assessment and toxicolog...

Preparation of Deep Sea Fish Oil-Based Nanostructured Lipid Carriers with Enhanced Cellular Uptake.

J. Nanosci. Nanotechnol. 15 , 9539-47, (2015)

Nanostructured lipid carriers (NLC) are a promising pharmaceutical delivery system with mean diameter less than 200 nm which are dispersed in an aqueous phase containing emulsifier(s), to increase the water solubility, stability and bioavailability of oil com...

Enhanced transdermal delivery of evodiamine and rutaecarpine using microemulsion.

Int. J. Nanomedicine 6 , 2469-82, (2011)

The purpose of this study was to improve skin permeation of evodiamine and rutaecarpine for transdermal delivery with microemulsion as vehicle and investigate real-time cutaneous absorption of the drugs via in vivo microdialysis.Pseudoternary phase diagrams w...