Dantrolene Sodium
Dantrolene Sodium structure
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Common Name | Dantrolene Sodium | ||
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| CAS Number | 14663-23-1 | Molecular Weight | 336.235 | |
| Density | N/A | Boiling Point | 85°C 4mm | |
| Molecular Formula | C14H9N4NaO5 | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | 283.1ºC | |
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Facilitatory effect of dopamine on neuromuscular transmission mediated via dopamine D1-like receptors and prospective interaction with nicotine.
Eur. J. Pharmacol. 765 , 51-7, (2015) The objective of this study is to probe the effects of dopamine and potential interactions with nicotine at the motor end plate. To accomplish this, we measured the amplitude of nerve-evoked muscle twitches of the isolated rat phrenic hemi-diaphragm preparati... |
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Identification of new MRP4 inhibitors from a library of FDA approved drugs using a high-throughput bioluminescence screen.
Biochem. Pharmacol. 93(3) , 380-8, (2015) Multidrug resistance protein 4 (MRP4) effluxes a wide variety of drugs and endogenous signaling molecules from cells and has been proposed as an attractive therapeutic target in several solid tumors, including neuroblastoma and colorectal cancer. MRP4 also re... |
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Brain penetration of WEB 2086 (Apafant) and dantrolene in Mdr1a (P-glycoprotein) and Bcrp knockout rats.
Drug Metab. Dispos. 42(10) , 1761-5, (2014) Transporter gene knockout rat models are attracting increasing interest for mechanistic studies of new drugs as transporter substrates or inhibitors in vivo. However, limited data are available on the functional validity of such models at the blood-brain barr... |
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Modulation by dantrolene of endotoxin-induced interleukin-10, tumour necrosis factor-alpha and nitric oxide production in vivo and in vitro.
Br. J. Pharmacol. 124 , 1099, (1998) 1. Intracellular calcium has been suggested to be an important mediator of the cellular response in endotoxaemia and shock. Dantrolene is an agent that interferes with intracellular calcium fluxes resulting in a decreased availability of calcium in the cytopl... |
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Increased intracellular Ca2+: a critical link in the pathophysiology of sepsis?
Proc. Natl. Acad. Sci. U. S. A. 90 , 3933, (1993) Severe bloodstream-borne infection--i.e., sepsis--and the resulting multiorgan failure are now the most common cause of death in many intensive care units. One of the most fundamentally important and controversial issues concerning the pathophysiology of seps... |
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Calcium channel blockers and dantrolene differentially regulate the production of interleukin-12 and interferon-gamma in endotoxemic mice.
Brain Res. Bull. 46 , 257, (1998) Recent studies suggested that transmitters released from the sympathetic nerve terminals can modulate various inflammatory responses by occupation of receptors on immune cells. These neurotransmitters act via alteration of intracellular concentration of secon... |