AM580
AM580 structure
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Common Name | AM580 | ||
|---|---|---|---|---|
| CAS Number | 102121-60-8 | Molecular Weight | 351.439 | |
| Density | 1.2±0.1 g/cm3 | Boiling Point | 461.0±45.0 °C at 760 mmHg | |
| Molecular Formula | C22H25NO3 | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | 232.6±28.7 °C | |
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The active enhancer network operated by liganded RXR supports angiogenic activity in macrophages.
Genes Dev. 28(14) , 1562-77, (2014) RXR signaling is predicted to have a major impact in macrophages, but neither the biological consequence nor the genomic basis of its ligand activation is known. Comprehensive genome-wide studies were carried out to map liganded RXR-mediated transcriptional c... |
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The bioactive lipid 4-hydroxyphenyl retinamide inhibits flavivirus replication.
Antimicrob. Agents Chemother. 59(1) , 85-95, (2014) Dengue virus (DENV), a member of the Flaviviridae family, is a mosquito-borne pathogen and the cause of dengue fever. The increasing prevalence of DENV worldwide heightens the need for an effective vaccine and specific antivirals. Due to the dependence of DEN... |
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Myeloid differentiation and retinoblastoma phosphorylation changes in HL-60 cells induced by retinoic acid receptor- and retinoid X receptor-selective retinoic acid analogs.
Blood 87 , 227-237, (1996) The ability of subtypes of retinoic acid receptors (RARs) and retinoid X receptors (RXRs) singly and in combination to elicit myeloid differentiation, G1/0-specific growth arrest, and retinoblastoma (RB) tumor suppressor protein dephosphorylation was determin... |
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BCL-xL/MCL-1 inhibition and RARγ antagonism work cooperatively in human HL60 leukemia cells.
Exp. Cell Res. 327(2) , 183-91, (2014) The acute promyelocytic leukemia (APL) subtype of acute myeloid leukemia (AML) is characterized by chromosomal translocations that result in fusion proteins, including the promyelocytic leukemia-retinoic acid receptor, alpha fusion protein (PML-RARα). All-tra... |
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Macrophages engulfing apoptotic cells produce nonclassical retinoids to enhance their phagocytic capacity.
J. Immunol. 192(12) , 5730-8, (2014) Previous work in our laboratory has shown that transglutaminase 2 (TG2) acting as a coreceptor for integrin β3 is required for proper phagocytosis of apoptotic cells. In the absence of TG2, systemic lupus erythematosus-like autoimmunity develops in mice, simi... |
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Retinoids activate the irritant receptor TRPV1 and produce sensory hypersensitivity.
J. Clin. Invest. 123(9) , 3941-51, (2013) Retinoids are structurally related derivatives of vitamin A and are required for normal vision as well as cell proliferation and differentiation. Clinically, retinoids are effective in treating many skin disorders and cancers. Application of retinoids evokes ... |
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Research resource: transcriptome profiling of genes regulated by RXR and its permissive and nonpermissive partners in differentiating monocyte-derived dendritic cells.
Mol. Endocrinol. 24 , 2218-2231, (2010) Retinoid X receptors (RXRs) are heterodimerization partners for many nuclear receptors and also act as homodimers. Heterodimers formed by RXR and a nonpermissive partner, e.g. retinoic acid receptor (RAR) and vitamin D receptor (VDR), can be activated only by... |
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The Retinoic Acid Receptor-alpha mediates human T-cell activation and Th2 cytokine and chemokine production.
BMC Immunol. 9 , 16, (2008) We have recently demonstrated that all-trans-retinoic acid (ATRA) and 9-cis-retinoic acid (9-cis RA) promote IL-4, IL-5 and IL-13 synthesis, while decreasing IFN-gamma and TNF-alpha expression by activated human T cells and reduces the synthesis of IL-12p70 f... |
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Myoepithelial and luminal breast cancer cells exhibit different responses to all-trans retinoic acid.
Cell. Oncol. (Dordr.) 38 , 289-305, (2015) Breast cancer is the leading cause of death among women worldwide. The exact role of luminal epithelial (LEP) and myoephitelial (MEP) cells in breast cancer development is as yet unclear, as also how retinoids may affect their behaviour. Here, we set out to e... |
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Retinoic acid receptor agonists regulate expression of ATP-binding cassette transporter G1 in macrophages.
Biochim. Biophys. Acta 1821(4) , 561-72, (2012) ABC transporter G1 (ABCG1) plays a pivotal role in HDL-mediated cholesterol efflux and atherogenesis. We investigated whether, and how, retinoic acid receptors (RARs) regulate ABCG1 expression in macrophages. All-trans retinoic acid (ATRA), an RAR ligand, inc... |