ALANINE RACEMASE
ALANINE RACEMASE structure
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Common Name | ALANINE RACEMASE | ||
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| CAS Number | 9024-06-0 | Molecular Weight | 268.223 | |
| Density | 1.7±0.1 g/cm3 | Boiling Point | N/A | |
| Molecular Formula | C11H12N2O6 | Melting Point | N/A | |
| MSDS | USA | Flash Point | N/A | |
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[Regulation of key enzymes of L-alanine biosynthesis by Brevibacterium flavum producer strains].
Prikl. Biokhim. Mikrobiol. 49(2) , 144-8, (2013) The mechanisms of L-alanine overproduction by Brevibacterium flavum producer strains were studied. It was shown that beta-CI-L-alanine is an inhibitor of some key enzymes involved in the synthesis of L-alanine, including alanine transaminase and valine-pyruva... |
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Removal of L-alanine from the production of L-2-aminobutyric acid by introduction of alanine racemase and D-amino acid oxidase.
Appl. Microbiol. Biotechnol. 90(3) , 903-10, (2011) L-2-Aminobutyric acid can be synthesized in a transamination reaction from L-threonine and L-aspartic acid as substrates by the action of threonine deaminase and aromatic aminotransferase, but the by-product L-alanine was produced simultaneously. A small amou... |
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Involvement of alanine racemase in germination of Bacillus cereus spores lacking an intact exosporium.
Arch. Microbiol. 196(2) , 79-85, (2014) The L-alanine mediated germination of food isolated Bacillus cereus DSA 1 spores, which lacked an intact exosporium, increased in the presence of D-cycloserine (DCS), which is an alanine racemase (Alr) inhibitor, reflecting the activity of the Alr enzyme, cap... |
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Determination of pyridoxal-5'-phosphate (PLP)-bonding sites in proteins: a peptide mass fingerprinting approach based on diagnostic tandem mass spectral features of PLP-modified peptides.
Rapid Commun. Mass Spectrom. 23(21) , 3401-8, (2009) Peptides modified by pyridoxal-5'-phosphate (PLP), linked to a lysine residue via reductive amination, exhibit distinct spectral characteristics in the collision-induced dissociation (CID) tandem mass (MS/MS) spectra that are described here. The MS/MS spectra... |
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Alanine racemase from Tolypocladium inflatum: a key PLP-dependent enzyme in cyclosporin biosynthesis and a model of catalytic promiscuity.
Arch. Biochem. Biophys. 529(2) , 55-65, (2013) Cyclosporin A, a cyclic peptide produced by the fungus Tolypocladium inflatum, is a widely employed immunosuppressant drug. Its biosynthesis is strictly dependent on the action of the pyridoxal 5'-phosphate-dependent enzyme alanine racemase, which produces th... |
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The crystal structure of alanine racemase from Streptococcus pneumoniae, a target for structure-based drug design.
BMC Microbiol. 11 , 116, (2011) Streptococcus pneumoniae is a globally important pathogen. The Gram-positive diplococcus is a leading cause of pneumonia, otitis media, bacteremia, and meningitis, and antibiotic resistant strains have become increasingly common over recent years. Alanine rac... |
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Evolution and multiplicity of arginine decarboxylases in polyamine biosynthesis and essential role in Bacillus subtilis biofilm formation.
J. Biol. Chem. 285(50) , 39224-38, (2010) Arginine decarboxylases (ADCs; EC 4.1.1.19) from four different protein fold families are important for polyamine biosynthesis in bacteria, archaea, and plants. Biosynthetic alanine racemase fold (AR-fold) ADC is widespread in bacteria and plants. We report t... |
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Role of the pyridine nitrogen in pyridoxal 5'-phosphate catalysis: activity of three classes of PLP enzymes reconstituted with deazapyridoxal 5'-phosphate.
J. Am. Chem. Soc. 133(37) , 14823-30, (2011) Pyridoxal 5'-phosphate (PLP; vitamin B(6))-catalyzed reactions have been well studied, both on enzymes and in solution, due to the variety of important reactions this cofactor catalyzes in nitrogen metabolism. Three functional groups are central to PLP cataly... |
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Alanine racemase mutants of Mycobacterium tuberculosis require D-alanine for growth and are defective for survival in macrophages and mice.
Microbiology 158(Pt 2) , 319-27, (2012) Alanine racemase (Alr) is an essential enzyme in most bacteria; however, some species (e.g. Listeria monocytogenes) can utilize d-amino acid transaminase (Dat) to generate d-alanine, which renders Alr non-essential. In addition to the conflicting reports on g... |
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ExsB, an unusually highly phosphorylated protein required for the stable attachment of the exosporium of Bacillus anthracis.
Mol. Microbiol. 76(6) , 1527-38, (2010) The outermost layer of the Bacillus anthracis spore, the exosporium, is composed of a paracrystalline basal layer and an external hair-like nap. The nap is formed from a single collagen-like glycoprotein, while the basal layer contains many different proteins... |