Elastase, human leucocytes
Elastase, human leucocytes structure
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Common Name | Elastase, human leucocytes | ||
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| CAS Number | 9004-06-2 | Molecular Weight | 326.476 | |
| Density | 1.1±0.1 g/cm3 | Boiling Point | 495.1±45.0 °C at 760 mmHg | |
| Molecular Formula | C21H30N2O | Melting Point | N/A | |
| MSDS | USA | Flash Point | 253.3±28.7 °C | |
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Prolonged exposure to neutrophil extracellular traps can induce mitochondrial damage in macrophages and dendritic cells.
Springerplus 4 , 161, (2015) Neutrophils are one the earliest, crucial innate defenses against innumerable pathogens. Their main microbicidal activities include phagocytosis and degranulation, with many pharmacologically active molecules contributing to inflammation. Recently, a novel an... |
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Clinically relevant cell sources for TMJ disc engineering.
J. Dent. Res. 87 , 548-52, (2010) Tissue-engineering of the temporomandibular joint (TMJ) disc aims to provide patients with TMJ disorders an option to replace diseased tissue with autologous, functional tissue. This study examined clinically relevant cell sources by comparing costal chondroc... |
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Human leukocyte and porcine pancreatic elastase: X-ray crystal structures, mechanism, substrate specificity, and mechanism-based inhibitors.
Biochemistry 28(5) , 1951-63, (1989)
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Prevention of hepatocarcinogenesis and increased susceptibility to acetaminophen-induced liver failure in transaldolase-deficient mice by N-acetylcysteine.
J. Clin. Invest. 119(6) , 1546-57, (2009) Although oxidative stress has been implicated in acute acetaminophen-induced liver failure and in chronic liver cirrhosis and hepatocellular carcinoma (HCC), no common underlying metabolic pathway has been identified. Recent case reports suggest a link betwee... |
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Hemodynamics and axial strain additively increase matrix remodeling and MMP-9, but not MMP-2, expression in arteries engineered by directed remodeling.
Tissue Eng. Part A 15(6) , 1281-90, (2009) We previously demonstrated the ability to create engineered arteries by carefully controlling the mechanical environment of intact arteries perfused ex vivo, yielding engineered arteries with native appearance and vasoactive response. Increased axial strain w... |
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Active site mapping of the serine proteases human leukocyte elastase, cathepsin G, porcine pancreatic elastase, rat mast cell proteases I and II. Bovine chymotrypsin A alpha, and Staphylococcus aureus protease V-8 using tripeptide thiobenzyl ester substrates.
Biochemistry 23 , 2995, (1984) The primary subsite specificities of human leukocyte elastase, cathepsin G, porcine pancreatic elastase, rat mast cell proteases I and II, bovine chymotrypsin A alpha, and the protease from strain V-8 of Staphylococcus aureus have been mapped with a series of... |
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The neutrophil elastase inhibitor sivelestat suppresses accelerated gastrointestinal tumor growth via peritonitis after cecal ligation and puncture.
Anticancer Res. 33(9) , 3653-9, (2013) We examined whether tumor growth is enhanced by cecal ligation and puncture (CLP) and suppressed by a neutrophil elastase inhibitor, sivelestat.C57BL/6 mice were divided in CLP/sivelestat, CLP alone, and control (simple laparotomy) groups. Murine CT26 colon c... |
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Inhibition of neutrophil elastase attenuates airway hyperresponsiveness and inflammation in a mouse model of secondary allergen challenge: neutrophil elastase inhibition attenuates allergic airway responses.
Respir. Res. 14 , 8, (2013) Chronic asthma is often associated with neutrophilic infiltration in the airways. Neutrophils contain elastase, a potent secretagogue in the airways, nonetheless the role for neutrophil elastase as well as neutrophilic inflammation in allergen-induced airway ... |
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Leukocyte activation markers and oxidative status in chronic kidney disease.
Minerva Urol. Nefrol. 65(1) , 69-76, (2013) In chronic kidney disease (CKD) cardiovascular risk is increased. Oxidative stress is strictly involved in the pathophysiology of this enhanced risk as well as leukocytes' activation. To better elucidate these phaenomena we evaluated some parameters of leukoc... |
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In vitro studies on the beneficial effect of a hydrokinetic fiber dressing on wound healing by reduction of protease activity.
J. Wound Care 22(11) , 592, 594-8, (2013) To test the binding capacity of a hydrokinetic fiber dressing for PMN elastase, MMP-2 and MMP-9 in vitro, and to determine whether testing of dressing material samples in vitro is sufficient to predict the performance of the whole dressing.In vitro protease b... |