tolnaftate
tolnaftate structure
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Common Name | tolnaftate | ||
|---|---|---|---|---|
| CAS Number | 2398-96-1 | Molecular Weight | 307.409 | |
| Density | 1.2±0.1 g/cm3 | Boiling Point | 453.4±38.0 °C at 760 mmHg | |
| Molecular Formula | C19H17NOS | Melting Point | 110.5-111.5ºC | |
| MSDS | Chinese USA | Flash Point | 228.0±26.8 °C | |
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Characterization of iprodione resistance in Botrytis cinerea from strawberry and blackberry.
Phytopathology 104(4) , 396-402, (2014) Gray mold, caused by the fungal pathogen Botrytis cinerea, is one of the most destructive diseases of strawberry. Control of the disease in commercial fields is largely dependent on the application of fungicides, including the dicarboximide iprodione. Single-... |
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DrugBank 3.0: a comprehensive resource for 'omics' research on drugs.
Nucleic Acids Res. 39 , D1035-41., (2011) DrugBank (http://www.drugbank.ca) is a richly annotated database of drug and drug target information. It contains extensive data on the nomenclature, ontology, chemistry, structure, function, action, pharmacology, pharmacokinetics, metabolism and pharmaceutic... |
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A randomised controlled trial of active chronic otitis media comparing courses of eardrops versus one-off topical treatments suitable for primary, secondary and tertiary healthcare settings.
Clin. Otolaryngol. 37(4) , 261-70, (2012) Primary: to compare one-off administration of boric acid powder with courses of 1% acetic acid and ciprofloxacin eardrops in treating active chronic otitis media. Secondary: to evaluate the effectiveness of Quadriderm® cream in resistant active chronic otitis... |
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X-ray powder diffractometric method for quantitation of crystalline drug in microparticulate systems. I. Microspheres.
J. Pharm. Sci. 91(4) , 983-90, (2002) Ethylcellulose microspheres containing tolnaftate (I) were prepared by the emulsion-solvent evaporation technique. An X-ray powder diffractometric method was developed to quantify the content of crystalline I in these microspheres. X-ray lines of I with d-spa... |
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Studies on the mode of action of tolnaftate in Microsporum gypseum.
J. Med. Vet. Mycol. 29(1) , 45-52, (1991) Studies were performed on the mode of action of tolnaftate and resistance to this drug in Microsporum gypseum. Cells grown in the presence of tolnaftate (at the IC 50) showed a reduced content of total phospholipids and sterols whereas there was an increase i... |
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Assay of tolnaftate and related impurities by isocratic supercritical fluid chromatography.
Fresenius J. Anal. Chem. 367(1) , 91-3, (2000) Tolnaftate, an antifungal drug (TF) and related impurities arising from synthesis, viz., N-methyl-m-toluidine (NMmT) and beta-naphthol-1-chlorothio carbamate (beta-NCTC) can be determined by supercritical fluid chromatography. Even though it was possible to e... |
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Nonplanar property study of antifungal agent tolnaftate-spectroscopic approach.
Spectrochim. Acta. A. Mol. Biomol. Spectrosc. 79(5) , 993-1003, (2011) Vibrational analysis of the thionocarbamate fungicide tolnaftate which is antidermatophytic, antitrichophytic and antimycotic agent, primarily inhibits the ergosterol biosynthesis in the fungus, was carried out using NIR FT-Raman and FTIR spectroscopic techni... |
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Study on the supramolecular multirecognition mechanism of beta-naphthol/beta-cyclodextrin/anionic surfactant in a tolnaftate hydrolysis system.
J. Phys. Chem. B 110(17) , 8877-84, (2006) Based on the fact that tolnaftate degrade to beta-naphthol sodium (RONa) at 5.00 mol/L NaOH solution and RO(-) was protonated to ROH after being acidified and adjusted to the pH 4.50 by acetic acid-sodium acetate buffer solution, we studied and discussed the ... |
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Identification of Hedgehog signaling inhibitors with relevant human exposure by small molecule screening.
Toxicol. In Vitro 24(5) , 1404-9, (2010) In animal models, chemical disruption of the Hedgehog (Hh) signaling pathway during embryonic development causes severe birth defects including holoprosencephaly and cleft lip and palate. The exact etiological basis of correlate human birth defects remains un... |
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Liquid chromatographic determination of tolnaftate in commercial products.
J. Assoc. Off. Anal. Chem. 74(4) , 603-7, (1991) A liquid chromatographic (LC) method for the determination of the antifungal agent tolnaftate was developed. Isolation of the analyte was achieved by direct extraction or dilution with acetonitrile-water (80 + 20) followed by reverse-phase liquid chromatograp... |