Metorphamide (free acid)
Metorphamide (free acid) structure
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Common Name | Metorphamide (free acid) | ||
|---|---|---|---|---|
| CAS Number | 88866-92-6 | Molecular Weight | 985.16400 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C44H68N14O10S | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | N/A | |
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MDR1 P-glycoprotein transports endogenous opioid peptides.
Peptides 22 , 2015-2020, (2001) MDR1 P-glycoprotein is generally regarded as an efflux pump for amphipathic toxic compounds. The question remains, however, whether certain endogenous compounds are also substrates for this transporter. Certain peptides have been shown to interact with MDR1 P... |
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Metorphamide, a novel endogenous adrenal opioid peptide, inhibits nicotine-induced secretion from bovine adrenal chromaffin cells.
Brain Res. 363 , 10-17, (1986) Opioid peptides are found in high concentrations in the adrenal medulla. Recently, a novel opioid octapeptide, metorphamide, possessing an amidated C-terminal, was characterized and also found to be present in adrenal tissue. We have studied the ability of th... |
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Opioid inhibition of nicotine-induced 45Ca2(+)-uptake into cultured bovine adrenal medullary cells.
Biochem. Pharmacol. 41 , 715-722, (1991) The ability of a number of opioid agonists and antagonists to affect nicotine-induced 45Ca2(+)-uptake into cultured bovine adrenal medullary cells has been investigated. High (10 microM) concentrations of the opioid agonist bremazocine produced a significant ... |
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Transport systems for opioid peptides in mammalian tissues.
AAPS J. 7 , E852-856, (2005) Transmembrane transport of endogenous as well as synthetic opioid peptides is a critical determinant of pharmacokinetics and biologic efficacy of these peptides. This transport process influences the distribution of opioid peptides across the blood-brain barr... |
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Studies on adrenorphin in pheochromocytoma.
J. Clin. Endocrinol. Metab. 64 , 692-677, (1987) We studied the secretion and tissue contents of adrenorphin in human pheochromocytomas. In 17 human pheochromocytomas from 11 patients, we found a remarkably wide distribution in immunoreactive adrenorphin levels (3-7771 pg/mg tissue). Adrenomedullary pheochr... |