stilbene oxide
stilbene oxide structure
|
Common Name | stilbene oxide | ||
|---|---|---|---|---|
| CAS Number | 1439-07-2 | Molecular Weight | 196.245 | |
| Density | 1.1±0.1 g/cm3 | Boiling Point | 304.5±11.0 °C at 760 mmHg | |
| Molecular Formula | C14H12O | Melting Point | 65-67 °C(lit.) | |
| MSDS | Chinese USA | Flash Point | 133.4±15.5 °C | |
|
Induction of multidrug resistance protein 3 in rat liver is associated with altered vectorial excretion of acetaminophen metabolites.
Drug Metab. Dispos. 31(9) , 1176-86, (2003) Treatment with the microsomal enzyme inducer trans-stilbene oxide (TSO) can decrease biliary excretion of acetaminophen-glucuronide (AA-GLUC) and increase efflux of AA-GLUC into blood. The hepatic canalicular multidrug resistance protein (Mrp) 2 and sinusoida... |
|
|
The metabolism of lysophosphatidic acids by allelic variants of human soluble epoxide hydrolase.
Drug Metab. Pharmacokinet. 30(1) , 75-81, (2015) Lysophosphatidic acids (LPAs) are phospholipids which have many physiological and pathophysiological functions. The human soluble epoxide hydrolase (sEH) plays a role in the metabolism of xenobiotics through its metabolism of aromatic hydrocarbon epoxides suc... |
|
|
A test to determine the nature and presence of the memory effect columns packed with the amylose tris(3,5-dimethylphenylcarbamate) stationary phase.
J. Chromatogr. A. 1218(37) , 6302-7, (2011) Acid/base mobile phase modifiers affect enantioseparations in ways that are not fully understood yet, for the lack of systematic studies. This makes chiral analysis of some pharmaceuticals difficult to reproduce. Once a column has been exposed to a modifier, ... |
|
|
Evaluation of injection conditions for preparative supercritical fluid chromatography.
J. Chromatogr. A. 1250 , 256-63, (2012) Preparative supercritical fluid chromatography (SFC) has become the preferred method for the rapid purification of drug candidates during the pharmaceutical discovery process. This paper will discuss the evaluation of injection techniques for preparative SFC.... |
|
|
Trans-stilbene oxide-induced sister chromatid exchange in cultured human lymphocytes: influence of GSTM1 and GSTT1 genotypes.
Mutagenesis 16(3) , 277-81, (2001) About 50% and 15% of Caucasians lack the glutathione S-transferase M1 (GSTM1) and T1 (GSTT1) genes and the corresponding enzyme activity, respectively. Both of these polymorphisms have been shown to affect the genotoxicity of some epoxides in cultured human l... |
|
|
Induction of genes for metabolism and transport by trans-stilbene oxide in livers of Sprague-Dawley and Wistar-Kyoto rats.
Drug Metab. Dispos. 34(7) , 1190-7, (2006) trans-Stilbene oxide (TSO) is a synthetic proestrogen that induces phase I and II drug-metabolizing enzymes in rat liver. The purpose of this study was to determine whether TSO also induces transporter expression in rat liver and whether gene induction in rat... |
|
|
Enantiomer self-disproportionation of chiral compounds on achiral ordered mesoporous silica M41S and regular silica gel as a stationary phase.
Chirality 21(2) , 255-61, (2009) Chromatographic behavior of nonracemic mixtures, viz., mandelic acid and stilbene oxide as analytes has been studied in detailed by enantiomer self-disproportionation on achiral ordered mesoporous material M41S and regular silica gel as stationary phases. Ena... |
|
|
Antitumor agents. Part 3: synthesis and cytotoxicity of new trans-stilbene benzenesulfonamide derivatives.
Bioorg. Med. Chem. Lett. 12(7) , 1013-5, (2002) A new series of trans-stilbene benzenesulfonamide derivatives were designed and synthesized as potential antitumor agents. These new compounds were evaluated in the National Cancer Institute's 60 human tumor cell line in vitro screen. Compounds 9-13 were cyto... |
|
|
The influence of the memory effect on preparative separations using the amylose tris(3,5-dimethylphenylcarbamate) stationary phase.
J. Chromatogr. A. 1218(31) , 5157-65, (2011) Acid/base mobile phase modifiers affect enantioseparations in ways that are not yet understood for the lack of systematic studies, which makes the scale-up of preparative separations difficult to predict. Shifts of the selectivity of certain pairs of enantiom... |
|
|
Non-synonymous single nucleotide alterations in the microsomal epoxide hydrolase gene and their functional effects.
Xenobiotica 33(3) , 277-87, (2003) 1. By sequencing genomic DNA from 72 established cell lines derived from Japanese individuals, we detected 25 single nucleotide alterations in the microsomal epoxide hydrolase (EPHX1) gene. Of them, five were exonic alterations resulting in amino acid alterat... |