Synthetase, Acetylcoenzyme A
Synthetase, Acetylcoenzyme A structure
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Common Name | Synthetase, Acetylcoenzyme A | ||
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| CAS Number | 9012-31-1 | Molecular Weight | 313.220 | |
| Density | 1.6±0.1 g/cm3 | Boiling Point | 583.2±50.0 °C at 760 mmHg | |
| Molecular Formula | C11H11N3O8 | Melting Point | N/A | |
| MSDS | USA | Flash Point | 306.5±30.1 °C | |
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Incomplete Wood-Ljungdahl pathway facilitates one-carbon metabolism in organohalide-respiring Dehalococcoides mccartyi.
Proc. Natl. Acad. Sci. U. S. A. 111(17) , 6419-24, (2014) The acetyl-CoA "Wood-Ljungdahl" pathway couples the folate-mediated one-carbon (C1) metabolism to either CO2 reduction or acetate oxidation via acetyl-CoA. This pathway is distributed in diverse anaerobes and is used for both energy conservation and assimilat... |
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The genome sequence of Propionibacterium acidipropionici provides insights into its biotechnological and industrial potential.
BMC Genomics 13 , 562, (2012) Synthetic biology allows the development of new biochemical pathways for the production of chemicals from renewable sources. One major challenge is the identification of suitable microorganisms to hold these pathways with sufficient robustness and high yield.... |
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Purification and characterization of the acetyl-CoA synthetase from Mycobacterium tuberculosis.
Acta Biochim. Biophys. Sin. (Shanghai) 43(11) , 891-9, (2011) Acetyl-CoA (AcCoA) synthetase (Acs) catalyzes the conversion of acetate into AcCoA, which is involved in many catabolic and anabolic pathways. Although this enzyme has been studied for many years in many organisms, the properties of Mycobacterium tuberculosis... |
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Role of motif III in catalysis by acetyl-CoA synthetase.
Archaea 2012 , 509579, (2012) The acyl-adenylate-forming enzyme superfamily, consisting of acyl- and aryl-CoA synthetases, the adenylation domain of the nonribosomal peptide synthetases, and luciferase, has three signature motifs (I-III) and ten conserved core motifs (A1-A10), some of whi... |
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SAGA complex components and acetate repression in Aspergillus nidulans.
G3 (Bethesda) 2(11) , 1357-67, (2012) Alongside the well-established carbon catabolite repression by glucose and other sugars, acetate causes repression in Aspergillus nidulans. Mutations in creA, encoding the transcriptional repressor involved in glucose repression, also affect acetate repressio... |
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Acetate is a bioenergetic substrate for human glioblastoma and brain metastases.
Cell 159(7) , 1603-14, (2014) Glioblastomas and brain metastases are highly proliferative brain tumors with short survival times. Previously, using (13)C-NMR analysis of brain tumors resected from patients during infusion of (13)C-glucose, we demonstrated that there is robust oxidation of... |
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Activity energy expenditure is a major determinant of dietary fat oxidation and trafficking, but the deleterious effect of detraining is more marked than the beneficial effect of training at current recommendations.
Am. J. Clin. Nutr. 98(3) , 648-58, (2013) Previous studies suggested that physical activity energy expenditure (AEE) is a major determinant of dietary fat oxidation, which is a central component of fat metabolism and body weight regulation.We tested this hypothesis by investigating the effect of cont... |
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Functional analyses of two acetyl coenzyme A synthetases in the ascomycete Gibberella zeae.
Eukaryotic Cell 10(8) , 1043-52, (2011) Acetyl coenzyme A (acetyl-CoA) is a crucial metabolite for energy metabolism and biosynthetic pathways and is produced in various cellular compartments with spatial and temporal precision. Our previous study on ATP citrate lyase (ACL) in Gibberella zeae revea... |
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Enhanced α-ketoglutarate production in Yarrowia lipolytica WSH-Z06 by alteration of the acetyl-CoA metabolism.
J. Biotechnol. 161(3) , 257-64, (2012) α-Ketoglutarate (α-KG) is an important intermediate in the tricarboxylic acid (TCA) cycle and has an important role in the regulation of the balance between carbon and nitrogen metabolism in most microorganisms. In previous research, a thiamine-auxotrophic ye... |
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A genome-wide screen for identifying all regulators of a target gene.
Nucleic Acids Res. 41(17) , e164, (2013) We have developed a new screening methodology for identifying all genes that control the expression of a target gene through genetic or metabolic interactions. The screen combines mutant libraries with luciferase reporter constructs, whose expression can be m... |