HIRUDIN LEECH, RECOMBINANT
HIRUDIN LEECH, RECOMBINANT structure
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Common Name | HIRUDIN LEECH, RECOMBINANT | ||
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| CAS Number | 8001-27-2 | Molecular Weight | 7027 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C287H440N80O110S6 | Melting Point | N/A | |
| MSDS | USA | Flash Point | N/A | |
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Contributions of multiple proteases to neurotoxicity in a mouse model of intracerebral haemorrhage.
Brain 132 , 26-36, (2009) Proteases such as matrix metalloproteinases (MMPs) and thrombin are implicated in intracerebral haemorrhage (ICH) but their interactions amongst one another and interdependency remain to be defined. The latter is important since proteases acting through diffe... |
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TNF Regulates Essential Alternative Complement Pathway Components and Impairs Activation of Protein C in Human Glomerular Endothelial Cells.
J. Immunol. 196 , 832-45, (2016) Atypical hemolytic uremic syndrome (aHUS) is a thrombotic microangiopathy with severe renal injury secondary to an overactive alternative complement pathway (AP). aHUS episodes are often initiated or recur during inflammation. We investigated gene expression ... |
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Differential neuroprotection and risk for bleeding from activated protein C with varying degrees of anticoagulant activity.
Stroke 40(5) , 1864-9, (2009) Activated protein C (APC), a protease with anticoagulant and cytoprotective activities, protects neurons and endothelium from ischemic injury. Drotrecogin-alfa activated, a hyperanticoagulant form of human recombinant APC, is currently being studied in patien... |
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Hirudin and hirudin-based peptides.
Meth. Enzymol. 223 , 312-336, (1993)
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Sequence-specific deamidation: isolation and biochemical characterization of succinimide intermediates of recombinant hirudin.
Biochemistry 32 , 725-734, (1993) Natural hirudin variant 2 with a lysine residue in position 47 (rHV2-Lys47) was produced in a genetically engineered strain of Saccharomyces cerevisiae as a secreted protein of 65 amino acids and purified to greater than 99% homogeneity. Only reversed-phase h... |
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[The reaction between hirudin and thrombin].
Hoppe. Seylers. Z. Physiol. Chem. 312 , 85-98, (1958)
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The effect of recombinant hirudin on rabbit ear flaps with venous insufficiency.
Indian J Plast Surg 47 , 102-8, (2014) The effect of recombinant hirudin, which is the most powerful antithrombotic agent, on flaps with venous insufficiency was investigated. Oedema and congestion are frequent on flaps, causing necrosis unpredictably. Venous insufficiency and thrombosis are exper... |
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Expression and Secretion in <I>S. Cerevisiae</I> of Biologically Active Leech Hirudin. Loison, G., et al.
Nat. Biotechnol. 6 , 72-77, (1988)
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The complete amino acid sequence of hirudin, a thrombin specific inhibitor: Application of colour carboxymethylation. Dodt, J., et al.
FEBS Lett. 165 , 180-184, (1984)
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Hirudin as an inhibitor of thrombin. Markwardt, F.
Meth. Enzymol. 19 , 924-932, (1970)
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