(d(CH2)51,Tyr(Me)2,Orn8)-Oxytocin trifluoroacetate salt
(d(CH2)51,Tyr(Me)2,Orn8)-Oxytocin trifluoroacetate salt structure
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Common Name | (d(CH2)51,Tyr(Me)2,Orn8)-Oxytocin trifluoroacetate salt | ||
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| CAS Number | 77327-45-8 | Molecular Weight | 1075.304 | |
| Density | 1.4±0.1 g/cm3 | Boiling Point | 1537.6±65.0 °C at 760 mmHg | |
| Molecular Formula | C48H74N12O12S2 | Melting Point | N/A | |
| MSDS | USA | Flash Point | 883.7±34.3 °C | |
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Oxytocin enhances, and oxytocin antagonism decreases, sexual receptivity in intact female rats.
Neuropeptides 27(4) , 245-50, (1994) In intact, non-ovariectomized female rats in spontaneous behavioral estrus, the i.c.v. injection of oxytocin significantly increased lordosis quotient and lordosis duration, starting from a dose of 1 ng/rat. On the other hand, the oxytocin antagonist, d(CH2)5... |
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Effect of oxytocin receptor antagonists on the renal actions of oxytocin and vasopressin in the rat.
J. Endocrinol. 152(2) , 257-64, (1997) The effect of three oxytocin receptor antagonists on the renal actions of oxytocin and vasopressin was investigated in conscious male rats infused with hypotonic saline. Infusion of oxytocin at 100 pg/min produced plasma concentrations of 12.7 +/- 3.3 pmol/l ... |
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The oxytocin antagonist d(CH2)5Tyr(Me)2-Orn8-vasotocin reduces non-contact penile erections in male rats.
Neurosci. Lett. 265(3) , 171-4, (1999) Male rats show four to six penile erection episodes when put for 80 min in the presence of an inaccessible receptive female. These non-contact penile erections were reduced dose-dependently by d(CH2)5Tyr(Me)2-Orn8-vasotocin, a potent and selective oxytocin re... |
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Comparison of vasopressin and oxytocin receptors in the rat uterus and vascular tissue.
Eur. J. Pharmacol. 308(1) , 87-96, (1996) Several studies indicate that oxytocin and vasopressin receptors in the human uterus are heterogeneous. We have investigated whether oxytocin and vasopressin bind to separate receptors in the day 21 and day 22 pregnant rat uterus and whether uterine vasopress... |
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Central blockade of oxytocin receptors during late gestation disrupts systemic release of oxytocin during suckling in rats.
J. Neuroendocrinol. 15(8) , 743-8, (2003) There is evidence that the central oxytocin system is activated and undergoes reorganization before parturition. The present study was designed to determine the effects of central oxytocin receptor blockade during late gestation on parturition, pup growth, an... |
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PD-168077, a selective dopamine D4 receptor agonist, induces penile erection when injected into the paraventricular nucleus of male rats.
Neurosci. Lett. 379(1) , 59-62, (2005) The effect of PD-168077 (N-methyl-4-(2-cyanophenyl)piperazynil-3-methylbenzamide maleate), a selective D4 dopamine receptor agonist, injected into the paraventricular nucleus of the hypothalamus on penile erection was studied in male rats. PD-168077 (1-200 ng... |
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Nitroglycerin-induced penile erection and yawning in male rats: mechanism of action in the brain.
Brain Res. Bull. 36(6) , 527-31, (1995) The effect of the central administration of nitroglycerin, a potent organic nitrate vasodilator, on penile erection and yawning was studied in male rats. When given intracerebroventricularly (ICV), nitroglycerin (33-99 micrograms) induced the above responses ... |
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Involvement of oxytocin in the nucleus tractus solitarii on central cardiovascular control: interactions with glutamate.
J. Physiol. Pharmacol. 61(1) , 59-65, (2010) Oxytocin (OT) is a peptide involved in several physiological functions in the central nervous system including central cardiovascular regulation. To clarify the role of endogenous OT in cardiovascular control, one group of anesthetized rats received unilatera... |
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Oxytocin mediates the inhibitory action of acute lithium on the morphine dependence in rats.
Neurosci. Res. 41(2) , 143-50, (2001) The role of central oxytocin in inhibitory action of lithium on the development of morphine dependence was behavioral investigated in rats. Acute lithium could enhance the morphine-induced analgesia in rats with or without chronic morphine treatment; this eff... |
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Brain oxytocin augments stress-induced long-lasting plasma adrenocorticotropic hormone elevation in rats.
Neurosci. Lett. 321(3) , 161-4, (2002) Single stress induces long-lasting changes in the hypothalamo-pituitary--adrenal (HPA) axis of adult animals. Selective oxytocin (OXT) receptor antagonist was administrated into the cerebroventricle of male rats to test its influence on plasma adrenocorticotr... |