Ramipril
Ramipril structure
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Common Name | Ramipril | ||
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| CAS Number | 87333-19-5 | Molecular Weight | 416.511 | |
| Density | 1.2±0.1 g/cm3 | Boiling Point | 616.2±55.0 °C at 760 mmHg | |
| Molecular Formula | C23H32N2O5 | Melting Point | 106-108°C | |
| MSDS | Chinese USA | Flash Point | 326.4±31.5 °C | |
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Clopidogrel bioactivation and risk of bleeding in patients cotreated with angiotensin-converting enzyme inhibitors after myocardial infarction: a proof-of-concept study.
Clin. Pharmacol. Ther. 96(6) , 713-22, (2014) Clopidogrel is an oral antiplatelet prodrug, the majority of which is hydrolyzed to an inactive metabolite by hepatic carboxylesterase 1 (CES1). Most angiotensin-converting enzyme inhibitors (ACEIs) are also metabolized by this enzyme. We examined the effects... |
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[Telangiectasia during amlodipine therapy].
Ann. Dermatol. Venereol. 140(3) , 202-5, (2013) Calcium inhibitors are recommended as first-line treatment in hypertension. We report the development of telangiectasia on the trunk and upper limbs in a female patient on amlodipine (Amlor(®)) that subsided on treatment discontinuation.A 63-year-old woman co... |
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Ramipril and hydrochlorothiazide treatment of hypertensive urgency in the ED.
Am. J. Emerg. Med. 31(10) , 1533-4, (2013)
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Effect of zofenopril and ramipril on cardiovascular mortality in patients with chronic heart failure.
Am. J. Cardiol. 112(1) , 90-3, (2013) A head-to-head evaluation of the effect of ramipril and zofenopril on the cardiovascular mortality rate of patients with chronic heart failure (HF) in the setting of clinical practice is not yet available. We prospectively enrolled 224 patients with all-cause... |
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Determination of ramipril in human plasma and its fragmentation by UPLC-Q-TOF-MS with positive electrospray ionization.
Acta. Pharm. 65 , 159-69, (2015) This report presents the application of ultra-performance liquid chromatography coupled to quadrupole time-of-flight mass spectrometry with positive electrospray ionization, to determine ramipril in human plasma. First, the proteins in human plasma were preci... |
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The direct renin inhibitor aliskiren improves vascular remodelling in transgenic rats harbouring human renin and angiotensinogen genes.
Clin. Sci. (Lond.) 125(4) , 183-9, (2013) In the present study, we tested the hypothesis that chronic treatment with the direct rennin inhibitor aliskiren improves the remodelling of resistance arteries in dTGR (double-transgenic rats). dTGR (5 weeks) were treated with aliskiren (3 mg/kg of body mass... |
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Ramipril protects the endothelium from high glucose-induced dysfunction through CaMKKβ/AMPK and heme oxygenase-1 activation.
J. Pharmacol. Exp. Ther. 350(1) , 5-13, (2014) This study aims to investigate the effects of ramipril (RPL) on endothelial dysfunction associated with diabetes mellitus using cultured human aortic endothelial cells (HAECs) and a type 2 diabetic animal model. The effect of RPL on vasodilatory function in f... |
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Ramipril: a review of its use in the prevention of cardiovascular outcomes.
Drugs 62 , 1381-405, (2002) Ramipril, an angiotensin-converting enzyme (ACE) inhibitor, is a prodrug which is rapidly hydrolysed after absorption to the active metabolite ramiprilat. Earlier trials have shown that ACE inhibitors, when given to patients with low ejection fractions, have ... |
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Ramipril in the treatment of vascular diseases.
Expert Opin. Pharmacother. 6(11) , 1911-9, (2005) Ramipril is an angiotensin-converting enzyme inhibitor that has been extensively studied in randomised, controlled clinical trials in patients with cardiovascular diseases. Therapy with ramipril in patients with various cardiovascular disorders has demonstrat... |
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[The role of ramipril in the therapy of diabetic nephropathy].
Orv. Hetil. 155(7) , 263-9, (2014) In the past two decades the number of diabetic patients has increased dramatically. According to the data of the International Diabetes Federation published in 2012, more than 371 million people suffer from diabetes mellitus, which is responsible for the deat... |