7,8,9,10-Tetrahydrobenzo[pqr]tetraphen-7-ol

7,8,9,10-Tetrahydrobenzo[pqr]tetraphen-7-ol Structure
7,8,9,10-Tetrahydrobenzo[pqr]tetraphen-7-ol structure
Common Name 7,8,9,10-Tetrahydrobenzo[pqr]tetraphen-7-ol
CAS Number 6272-55-5 Molecular Weight 272.340
Density 1.3±0.1 g/cm3 Boiling Point 508.5±19.0 °C at 760 mmHg
Molecular Formula C20H16O Melting Point 142-144ºC(lit.)
MSDS Chinese USA Flash Point 189.2±13.7 °C

Synthesis of (+/-)-trans-7,8-Dihydrodiol of 6-Fluoro-benzo[a]pyrene via Hydroxyl-Directed Regioselective Functionalization of Substituted Pyrene.

J. Org. Chem. 64(6) , 1902-1907, (1999)

Synthesis of (+/-)-trans-7,8-dihydroxy-6-fluoro-7,8-dihydrobenzo[a]pyrene, the metabolite from 6-fluoro-benzo[a]pyrene, is described. Position 6 of 7,8,9,10-tetrahydrobenzo[a]pyren-7-ol (1) was functionalized by bromination with N-bromosaccharin. Regioselecti...

Recent Progress in the Use of N-Halo Compounds in Organic Synthesis. Veisi H, et al.

Org. Prep. Proced. Int. 43(6) , 489-540, (2011)

Sulfotransferase-mediated activation of 7,8,9,10-tetrahydro-7-ol, 7,8-dihydrodiol, and 7,8,9,10-tetraol derivatives of benzo[a]pyrene.

Chem. Res. Toxicol. 8(5) , 693-8, (1995)

Some hydroxymethyl-substituted polycyclic aromatic hydrocarbons have been shown to be converted to electrophilic, mutagenic, or tumorigenic sulfuric acid ester metabolites by cytosolic sulfotransferase activity in rodent liver. Likewise, certain types of arom...

Fluorescence-line-narrowed spectra of polycyclic aromatic carcinogen-DNA adducts.

Science 223(4633) , 289-91, (1984)

The laser excited fluorescence-line-narrowed spectrum of DNA modified with (+/-)-r-7,t-8-dihydroxy-t-9,10-epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene (BPDE), the ultimate carcinogenic metabolite of benzo[a]pyrene (BP), has been obtained in a water-glycerol-ethano...