CX546
CX546 structure
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Common Name | CX546 | ||
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| CAS Number | 215923-54-9 | Molecular Weight | 247.29000 | |
| Density | 1.215g/cm3 | Boiling Point | 422.8ºC at 760 mmHg | |
| Molecular Formula | C14H17NO3 | Melting Point | N/A | |
| MSDS | USA | Flash Point | 209.5ºC | |
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Ketamine-induced antidepressant effects are associated with AMPA receptors-mediated upregulation of mTOR and BDNF in rat hippocampus and prefrontal cortex.
Eur. Psychiatry 29(7) , 419-23, (2014) Ketamine exerts fast acting, robust, and lasting antidepressant effects in a sub-anesthetic dose, however, the underlying mechanisms are still not fully elucidated. Recent studies have suggested that ketamine's antidepressant effects are probably attributed t... |
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Benzamide-type AMPA receptor modulators form two subfamilies with distinct modes of action.
J. Pharmacol. Exp. Ther. 303 , 1075-1085, (2002) CX516 (BDP-12) and CX546, two first-generation benzamide-type AMPA receptor modulators, were compared with regard to their influence on AMPA receptor-mediated currents, autaptic responses in cultured hippocampal neurons, hippocampal excitatory postsynaptic cu... |
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Allosteric modulation of AMPA-type glutamate receptors increases activity of the promoter for the neural cell adhesion molecule, N-CAM.
Proc. Natl. Acad. Sci. U. S. A. 95 , 2597-2602, (1998) To study regulation in vivo of the promoter for the neural cell adhesion molecule, N-CAM, we have used homologous recombination to insert the bacterial lacZ gene between the transcription and translation initiation sites of the N-CAM gene. This insertion disr... |
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Micro-electrode array recordings reveal reductions in both excitation and inhibition in cultured cortical neuron networks lacking Shank3.
Mol. Psychiatry 21 , 159-68, (2016) Numerous risk genes have recently been implicated in susceptibility to autism and schizophrenia. Translating such genetic findings into disease-relevant neurobiological mechanisms is challenging due to the lack of throughput assays that can be used to assess ... |
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Ampakines: Labelling with 11C for PET distribution studies. Rogers, et al.
J. Labelled Comp. Radiopharm. 40 , 645-647, (1997)
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