Tetrandrine
Tetrandrine structure
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Common Name | Tetrandrine | ||
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| CAS Number | 518-34-3 | Molecular Weight | 622.750 | |
| Density | 1.2±0.1 g/cm3 | Boiling Point | 710.5±60.0 °C at 760 mmHg | |
| Molecular Formula | C38H42N2O6 | Melting Point | 219-222ºC | |
| MSDS | Chinese USA | Flash Point | 175.8±30.1 °C | |
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Cheminformatics analysis of assertions mined from literature that describe drug-induced liver injury in different species.
Chem. Res. Toxicol. 23 , 171-83, (2010) Drug-induced liver injury is one of the main causes of drug attrition. The ability to predict the liver effects of drug candidates from their chemical structures is critical to help guide experimental drug discovery projects toward safer medicines. In this st... |
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[Anti-tumor effect of tanshinone II A, tetrandrine, honokiol, curcumin, oridonin and paeonol on leukemia cell lines].
Sichuan Da Xue Xue Bao. Yi Xue Ban 43(3) , 362-6, (2012) To study the anti-tumor effect of tanshinon II A, tetrandrine, honokiol, curcumin, oridonin and paeonol on leukemia cell lines SUP-B15, K562, CEM, HL-60 and NB4.To study the anti-tumor effect of tanshinone II A, tetrandrine, honokiol, curcumin, The leukemia c... |
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Precision-cut liver slices as a model for the early onset of liver fibrosis to test antifibrotic drugs.
Toxicol. Appl. Pharmacol. 274(2) , 328-38, (2014) Induction of fibrosis during prolonged culture of precision-cut liver slices (PCLS) was reported. In this study, the use of rat PCLS was investigated to further characterize the mechanism of early onset of fibrosis in this model and the effects of antifibroti... |
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Tetrandrine enhances the anticancer effects of arsenic trioxide in vitro.
Int. J. Clin. Pharmacol. Ther. 52(5) , 416-24, (2014) Arsenic trioxide (As2O3), an effective agent to treat leukemia and other solid tumors, is largely limited by its toxicity. QT prolongation, torsades de pointes and sudden death have been implicated in the cardiotoxicity of As2O3. The present study was designe... |
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CHMIS-C: a comprehensive herbal medicine information system for cancer.
J. Med. Chem. 48 , 1481-8, (2005) A comprehensive herbal medicine information system for cancer (CHMIS-C) has been developed. The current version of the database integrates information on more than 200 anticancer herbal recipes that have been used for the treatment of different types of cance... |
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The interaction of telomere DNA G-quadruplex with three bis-benzyltetrahydroisoquinoline alkaloids.
Nucleic Acid Ther. 21(6) , 415-22, (2011) Telomeres are important multifunctional nucleoprotein structures located at the ends of eukaryotic chromosomes. Telomerase regulates telomere elongation, and its activity is associated with tumorigenesis. Because the activity of telomerase can be inhibited by... |
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Interaction of cepharanthine with immobilized heat shock protein 90α (Hsp90α) and screening of Hsp90α inhibitors.
Anal. Biochem. 434(1) , 202-6, (2013) Heat shock protein 90α (Hsp90α) immobilized on aminopropyl silica gels was prepared via the N- or C-terminal, which was termed Hsp90α-NT or Hsp90α-CT, respectively. Binding interactions of biscoclaurine alkaloids (cepharanthine (CEP), berbamine (BBM), isotetr... |
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Proteomic analysis reveals that Adh1p is involved in a synergistic fluconazole and tetrandrine mechanism against Candida albicans.
Pharmazie 68(12) , 951-4, (2013) We previously showed that Adh1p participates in fluconazole (FLC) resistance in Candida albicans through a mechanism that may involve efflux pumps. We also found that the concomitant use of tetrandrine (TET) and FLC provided a synergistic action against C. al... |
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c-Jun NH2-terminal kinase-induced proteasomal degradation of c-FLIPL/S and Bcl2 sensitize prostate cancer cells to Fas- and mitochondria-mediated apoptosis by tetrandrine.
Biochem. Pharmacol. 91(4) , 457-73, (2014) Tetrandrine, a constituent of Chinese herb Stephania tetrandra, causes cell death in prostate cancer, but the molecular mechanisms leading to apoptosis is not known. Here we demonstrated that tetrandrine selectively inhibits the growth of prostate cancer PC3 ... |
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The mechanism of antibacterial activity of tetrandrine against Staphylococcus aureus.
Foodborne Pathog. Dis. 9(8) , 686-91, (2012) Tetrandrine (TET) is a bis-benzylisoquinoline alkaloid derived from the radix of Stephania tetrandra S. Moore. TET performs a wide spectrum of biological activities. The radix of S. tetrandrae has been used traditionally in Asia, including Korea, to treat con... |