Geniposide
Geniposide structure
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Common Name | Geniposide | ||
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| CAS Number | 24512-63-8 | Molecular Weight | 388.366 | |
| Density | 1.5±0.1 g/cm3 | Boiling Point | 641.4±55.0 °C at 760 mmHg | |
| Molecular Formula | C17H24O10 | Melting Point | 161-162ºC | |
| MSDS | Chinese USA | Flash Point | 231.5±25.0 °C | |
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The effects of notoginsenoside R₁ on the intestinal absorption of geniposide by the everted rat gut sac model.
J. Ethnopharmacol. 142(1) , 136-43, (2012) Geniposide is derived from Gardenia jasminoides Ellis (Rubiaceae). Its anti-inflammatory, antithrombotic effects as well as its preventive effect against ischemic stroke have been reported. Radix notoginseng (Chinese name tienchi or sanqi) is the dried root o... |
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[Effects of geniposide on SNP-induced apoptosis of chondrocyte and cell cycle].
Zhongguo Gu Shang 26(3) , 232-5, (2013) To study the effects of Geniposide on SNP(sodium nitroprusside)-induced apoptosis of chondrocyte in vitro and cell cycle.The chondrocyte of three-week-old SD rats were separated and cultivated. The second generation of chondrocyte cells were involved in exper... |
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Pharmacokinetics of geniposide by monoclonal antibody-based icELISA in mice after oral administration of Huanglian-Jiedu-Tang.
Biol. Pharm. Bull. 37(9) , 1525-33, (2014) Geniposide, Geniposide, the main active component in extracts of Gardenia jasminoides ELLIS., is one of the main components of Huanglian-Jiedu-Tang (HJT). This study aimed to validate an indirect competitive enzyme-linked immunosorbent assay (icELISA) based o... |
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Natural borneol enhances geniposide ophthalmic absorption in rabbits.
Int. J. Pharm. 445(1-2) , 163-70, (2013) The purpose of this study was to investigate the effects of natural borneol (NB) on the pharmacokinetics and bioavailability of ophthalmic administered geniposide (Ge) in rabbits. In vitro permeability characteristics of Ge in excised rabbit corneas were eval... |
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Enrichment and purification of gardenia yellow from Gardenia jasminoides var. radicans Makino by column chromatography technique.
J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 893-894 , 43-8, (2012) In present study, the performance and separation characteristics of nine macroporous resins for the enrichment and purification of gardenia yellow from Gardenia jasminoides var. radicans Makino have been evaluated. The adsorption and desorption properties of ... |
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Antithrombotic activities of aqueous extract from Gardenia jasminoides and its main constituent.
Pharm. Biol. 51(2) , 221-5, (2013) Gardenia jasminoides J. Ellis (Rubiaceae) is a shrub tree species distributed all over the world. Now its pharmacological activities such as anti-atherosclerosis have been extensively studied.To offer pharmacological proof for its further clinical application... |
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Geniposide reduces inflammatory responses of oxygen-glucose deprived rat microglial cells via inhibition of the TLR4 signaling pathway.
Neurochem. Res. 37(10) , 2235-48, (2012) Geniposide, an iridoid glycoside isolated from Gardenia, has neuroprotective activities against oxidative stress and inflammation. The present study investigated the in vivo protective effect of geniposide on ischemia/reperfusion-injured rats by middle cerebr... |
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The different inhibitory effects of Huang-Lian-Jie-Du-Tang on cyclooxygenase 2 and 5-lipoxygenase.
J. Ethnopharmacol. 143(2) , 732-9, (2012) Huang-Lian-Jie-Du-Tang (HLJDT), a famous traditional Chinese prescription with wide anti-inflammatory applications, is an aqueous extract of four herbal materials: Rhizoma coptidis, Radix scutellariae, Cortex phellodendri, and Fructus gardeniae. Its effects o... |
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LPS-induced iNOS expression in N9 microglial cells is suppressed by geniposide via ERK, p38 and nuclear factor-κB signaling pathways.
Int. J. Mol. Med. 30(3) , 561-8, (2012) Activated microglia producing reactive nitrogen species, inflammatory factors, reactive oxygen species (ROS) and other neurovirulent factors, can lead to the development of neurodegenerative diseases. Certain compounds can inhibit the activation of microglia.... |
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Glucagon-like peptide 1 receptor plays an essential role in geniposide attenuating lipotoxicity-induced β-cell apoptosis.
Toxicol. In Vitro 26(7) , 1093-7, (2012) β-Cell apoptosis is considered to be a major cause of loss of β cells in diabetes. Geniposide could prevent oxidative stress-induced neuron apoptosis, and improved glucose stimulated insulin secretion by activating glucagon-like peptide 1 receptor (GLP-1R) in... |