5-BROMO-6-CHLORO-3-INDOLYL PHOSPHATE P-TOLUIDINE SALT

5-BROMO-6-CHLORO-3-INDOLYL PHOSPHATE P-TOLUIDINE SALT Structure
5-BROMO-6-CHLORO-3-INDOLYL PHOSPHATE P-TOLUIDINE SALT structure
Common Name 5-BROMO-6-CHLORO-3-INDOLYL PHOSPHATE P-TOLUIDINE SALT
CAS Number 6769-80-8 Molecular Weight 433.62100
Density N/A Boiling Point 580.2ºC at 760 mmHg
Molecular Formula C15H15BrClN2O4P Melting Point 198-200ºC
MSDS Chinese USA Flash Point 304.7ºC

Premature chromosome condensation induced by caffeine, 2-aminopurine, staurosporine and sodium metavanadate in S-phase arrested HeLa cells is associated with a decrease in Chk1 phosphorylation, formation of phospho-H2AX and minor cytoskeletal rearrangements.

Histochem. Cell Biol. 135(3) , 263-80, (2011)

Here, we demonstrate that in HeLa cells, Ser317 of Chk1 undergoes phosphorylation in response to replication stress induced by hydroxyurea. We also demonstrate the existence of constitutive (interphase and mitotic) Chk1 kinase phosphorylation, the translocati...