Tropisetron hydrochloride
Tropisetron hydrochloride structure
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Common Name | Tropisetron hydrochloride | ||
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| CAS Number | 105826-92-4 | Molecular Weight | 320.814 | |
| Density | N/A | Boiling Point | 448.5ºC at 760 mmHg | |
| Molecular Formula | C17H21ClN2O2 | Melting Point | 283-285ºC | |
| MSDS | USA | Flash Point | 225ºC | |
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Determination of tropisetron in human plasma by high performance liquid chromatographic method with UV detection and its application to a bioequivalence study.
J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 846(1-2) , 20-3, (2007) A simple and sensitive high performance liquid chromatography method with UV detection was described for the determination of tropisetron in human plasma. The prepared sample solution was injected onto BDS-C(8) reversed column using a mixture of ammonium acet... |
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Inhibition of 5-hydroxytryptamine- and enterotoxin-induced fluid secretion by 5-HT receptor antagonists in the rat jejunum.
Eur. J. Pharmacol. 248 , 157, (1993) The effects of cholera toxin and heat stable Escherichia coli (E. coli) enterotoxin on intestinal fluid secretion are commonly considered to be mediated by cyclic nucleotides. It was demonstrated recently, by using the 5-hydroxytryptamine (5-HT)2 receptor ant... |
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Effects of 5-hydroxytryptamine 3 receptor antagonists on gastrointestinal motor activity in conscious dogs.
J. Pharmacol. Exp. Ther. 256 , 272, (1991) We studied the effect of 5-hydroxytryptamine 3 (5-HT3) receptor antagonists on gastrointestinal (GI) motor activity in conscious dogs with force transducers implanted chronically. During the digestive state, GR38032F, BRL 43694 and ICS 205-930 did not affect ... |
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5-HT3 receptor antagonists inhibit morphine-induced stimulation of mesolimbic dopamine release and function in the rat.
Eur. J. Pharmacol. 230 , 63, (1993) The effects of three different 5HT3 receptor antagonists, granisetron, ICS 205-930 and ondansetron (0.01, 0.1 and 1 mg/kg, s.c.) were tested on changes in mesolimbic dopamine function produced by 1 mg/kg of morphine in the rat. Increases of in vivo dopamine r... |
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Presynaptic inhibitory effects of fluvoxamine, a selective serotonin reuptake inhibitor, on nociceptive excitatory synaptic transmission in spinal superficial dorsal horn neurons of adult mice.
J. Pharmacol. Sci. 126(2) , 136-45, (2014) Fluvoxamine, a selective serotonin (5-HT) reuptake inhibitor, has been shown to exert analgesic effects in humans and laboratory animals. However, its effects on spinal nociceptive synaptic transmission have not been fully characterized. Here, whole-cell reco... |