Levosulpiride
Levosulpiride structure
|
Common Name | Levosulpiride | ||
|---|---|---|---|---|
| CAS Number | 23672-07-3 | Molecular Weight | 341.426 | |
| Density | 1.2±0.1 g/cm3 | Boiling Point | N/A | |
| Molecular Formula | C15H23N3O4S | Melting Point | 183-186 °C(lit.) | |
| MSDS | Chinese USA | Flash Point | N/A | |
|
Chemical genetics reveals a complex functional ground state of neural stem cells.
Nat. Chem. Biol. 3(5) , 268-273, (2007) The identification of self-renewing and multipotent neural stem cells (NSCs) in the mammalian brain holds promise for the treatment of neurological diseases and has yielded new insight into brain cancer. However, the complete repertoire of signaling pathways ... |
|
|
The use of dried blood spots for quantification of 15 antipsychotics and 7 metabolites with ultra-high performance liquid chromatography - tandem mass spectrometry.
Drug Test. Anal. 7 , 502-11, (2015) Therapeutic drug monitoring of antipsychotics is important in optimizing individual therapy. In psychiatric populations, classical venous blood sampling is experienced as frightening. Interest in alternative techniques, like dried blood spots (DBS), has conse... |
|
|
5-HT2A receptor activation is necessary for CO2-induced arousal.
J. Neurophysiol. 114 , 233-43, (2015) Hypercapnia-induced arousal from sleep is an important protective mechanism pertinent to a number of diseases. Most notably among these are the sudden infant death syndrome, obstructive sleep apnea and sudden unexpected death in epilepsy. Serotonin (5-HT) pla... |
|
|
Liquid chromatography-tandem mass spectrometry quantification of levosulpiride in human plasma and its application to bioequivalence study.
J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 878(24) , 2280-5, (2010) An improved method for determining levels of levosulpiride in human plasma using ultra-performance liquid chromatography-tandem mass spectrometry (UPLC-MS/MS) was developed and validated. The protein precipitation method was used for plasma sample preparation... |
|
|
Influence of ABCB1 genetic polymorphisms on the pharmacokinetics of levosulpiride in healthy subjects.
Neuroscience 169(1) , 378-87, (2010) The purposes of this study were to clarify the involvement of P-glycoprotein in the absorption of levosulpiride in knockout mice that lack the Abcb1a/ 1b gene, and to evaluate the relationship between genetic polymorphisms in ABCB1 (exon 12, 21 and 26) and le... |
|
|
Diabetes mellitus and drug-induced Parkinsonism: a case-control study.
J. Neurol. Sci. 284(1-2) , 140-3, (2009) To investigate if diabetes is more common in drug-induced parkinsonism patients. We performed a hospital-based retrospective case-control study on 44 drug-induced parkinsonism (DIP) patients, 177 Parkinson disease patients, and 176 acute stroke patients match... |
|
|
Rapid quantification of levosulpiride in human plasma using RP-HPLC-MS/MS for pharmacokinetic and bioequivalence study.
Biomed. Chromatogr. 23(12) , 1350-6, (2009) A rapid and validated method for analysis of levosulpiride in human plasma using liquid chromatography coupled to tandem mass spectrometry was developed. Levosulpiride and tiapride (IS, internal standard) were extracted from alkalized plasma samples with ethy... |
|
|
Citalopram and levosulpiride: a dangerous drug combination for QT prolongation.
Am. J. Emerg. Med. 31(11) , 1624.e1-2, (2013) We report the case of an 89-year-old female patient who presented to the emergency department after out-of-hospital cardiac arrest due to polymorphic ventricular tachycardia treated by public access defibrillation. The admission electrocardiogram (ECG) showed... |
|
|
Levosulpiride, (S)-(-)-5-Aminosulfonyl-N-[(1-ethyl-2-pyrrolidinyl) methyl]-2-methoxybenzamide, enhances the transduction efficiency of PEP-1-ribosomal protein S3 in vitro and in vivo.
BMB Rep. 44(5) , 329-34, (2011) Many proteins with poor transduction efficiency were reported to be delivered to cells by fusion with protein transduction domains (PTDs). In this study, we investigated the effect of levosulpiride on the transduction of PEP-1 ribosomal protein S3 (PEP-1-rpS3... |
|
|
Pharmacokinetics and bioequivalence evaluation of 2 levosulpiride preparations after a single oral dose in healthy male Korean volunteers.
Int. J. Clin. Pharmacol. Ther. 42(3) , 174-80, (2004) To evaluate the bioequivalence of a single oral 25 mg dose of 2 levosulpiride preparations in healthy male Korean volunteers.The study was conducted as a randomized, 2-period crossover design in 28 healthy male Korean volunteers who received a single oral dos... |