(E/Z)-Polydatin
(E/Z)-Polydatin structure
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Common Name | (E/Z)-Polydatin | ||
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| CAS Number | 65914-17-2 | Molecular Weight | 407.39100 | |
| Density | 1.521 g/cm3 | Boiling Point | 707.7ºC at 760 mmHg | |
| Molecular Formula | C20H22O8 | Melting Point | 223-226 °C(lit.) | |
| MSDS | USA | Flash Point | 381.8ºC | |
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Protective effect of polydatin against burn-induced lung injury in rats.
Respir. Care 59(9) , 1412-21, (2014) Polydatin (PD) has anti-inflammatory and anti-apoptotic effects in ischemic-reperfusion injury. Moreover, inflammatory responses and apoptosis play a role in the development of burn-induced lung injuries. Based on these findings, in this study we investigated... |
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Nephroprotective Effects of Polydatin against Ischemia/Reperfusion Injury: A Role for the PI3K/Akt Signal Pathway.
Oxid. Med. Cell. Longev. 2015 , 362158, (2015) Oxidative stress and inflammation are involved in the pathogenesis in renal ischemia/reperfusion (I/R) injury. It has been demonstrated that polydatin processed the antioxidative, anti-inflammatory, and nephroprotective properties. However, whether it has ben... |
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Pre-column incubation followed by fast liquid chromatography analysis for rapid screening of natural methylglyoxal scavengers directly from herbal medicines: case study of Polygonum cuspidatum.
J. Chromatogr. A. 1286 , 102-10, (2013) Methylglyoxal (MGO), a very reactive metabolite of glucose, plays a pivotal role in the pathogenesis of several chronic diseases associated with diabetes, and it has been validated as an attractive target for them. In the present study, a simple and effective... |
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Chemical constituents of Caesalpinia decapetala (Roth) Alston.
Molecules 18(1) , 1325-36, (2013) The current study targets the chemical constituents of Caesalpinia decapetala (Roth) Alston and investigates the bioactivities of the isolated compounds. Fourteen known compounds were isolated using column chromatography, and structural identification was per... |
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Antihyperuricemic and nephroprotective effects of resveratrol and its analogues in hyperuricemic mice.
Mol. Nutr. Food. Res. 56(9) , 1433-44, (2012) Stilbenes, of which, resveratrol is a representative compound in foods and plants, possess a variety of bioactivities including antioxidation, anti-inflammation, chemoprevention, and cardioprotection. This study was conducted to evaluate the antihyperuricemic... |
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Polydatin ameliorates experimental diabetes-induced fibronectin through inhibiting the activation of NF-κB signaling pathway in rat glomerular mesangial cells.
Mol. Cell. Endocrinol. 362(1-2) , 183-93, (2012) A number of studies have recently demonstrated the involvement of nuclear factor-kappa B (NF-κB) activation and the subsequent coordinated inflammatory responses in the pathogenesis of diabetic nephropathy (DN). Polydatin has been shown to have the ability of... |
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Multiparameter evaluation of the longevity in C. elegans under stress using an integrated microfluidic device.
Biomed. Microdevices 14(4) , 721-8, (2012) Caenorhabditis elegans (C. elegans) is an excellent model organism for the study of aging and longevity. In this work, we presented a microfluidic approach for the evaluation of longevity in C. elegans under stress. The microfluidic device integrated multiple... |
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Creation of resveratrol-enriched rice for the treatment of metabolic syndrome and related diseases.
PLoS ONE 8(3) , e57930, (2013) Resveratrol has been clinically shown to possess a number of human health benefits. As a result, many attempts have been made to engineer resveratrol production in major cereal grains but have been largely unsuccessful. In this study, we report the creation o... |
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Protective effects of polydatin on septic lung injury in mice via upregulation of HO-1.
Mediators Inflamm. 2013 , 354087, (2013) The present study was carried out to investigate the effects and mechanisms of polydatin (PD) in septic mice. The model of cecal ligation and puncture (CLP-)induced sepsis was employed. Pretreatment of mice with PD (15, 45, and 100 mg/kg) dose-dependently red... |
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Polydatin, a natural precursor of resveratrol, induces β-defensin production and reduces inflammatory response.
Inflammation 36(1) , 26-34, (2013) It is well known that human keratinocytes produce the anti-microbial peptide β-defensin 2. Its production is enhanced by pathogenic microorganisms or other environmental stressors. In this study, we evaluated the effect of resveratrol, a polyphenol found in s... |