Fmoc-Lys(Boc)-OH
Fmoc-Lys(Boc)-OH structure
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Common Name | Fmoc-Lys(Boc)-OH | ||
|---|---|---|---|---|
| CAS Number | 71989-26-9 | Molecular Weight | 468.542 | |
| Density | 1.2±0.1 g/cm3 | Boiling Point | 685.7±55.0 °C at 760 mmHg | |
| Molecular Formula | C26H32N2O6 | Melting Point | 130-135 °C (dec.) | |
| MSDS | Chinese USA | Flash Point | 368.5±31.5 °C | |
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Quantification of plasma HIV RNA using chemically engineered peptide nucleic acids.
Nat. Commun. 5 , 5079, (2014) The remarkable stability of peptide nucleic acids (PNAs) towards enzymatic degradation makes this class of molecules ideal to develop as part of a diagnostic device. Here we report the development of chemically engineered PNAs for the quantitative detection o... |
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Diels-Alder hydrogels with enhanced stability: First step toward controlled release of bevacizumab.
Eur. J. Pharm. Biopharm. 96 , 217-25, (2015) Eight-armed PEG was functionalized with furyl and maleimide groups (8armPEG20k-Fur and 8armPEG20k-Mal); degradable hydrogels were obtained by cross-linking via Diels-Alder chemistry. To increase the stability to degradation, the macromonomers were modified by... |
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Chemical synthesis of a polypeptide backbone derived from the primary sequence of the cancer protein NY-ESO-1 enabled by kinetically controlled ligation and pseudoprolines.
Biopolymers 104 , 116-27, (2015) The cancer protein NY-ESO-1 has been shown to be one of the most promising vaccine candidates although little is known about its cellular function. Using a chemical protein strategy, the 180 amino acid polypeptide, tagged with an arginine solubilizing tail, w... |
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Identification of FAK substrate peptides via colorimetric screening of a one-bead one-peptide combinatorial library.
J. Pept. Sci. 21(4) , 302-11, (2015) Focal adhesion kinase (FAK) is a protein tyrosine kinase that is associated with regulating cellular functions such as cell adhesion and migration and has emerged as an important target for cancer research. Short peptide substrates that are selectively and ef... |
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New amphiphilic N-phosphoryl oligopeptides designed for gene delivery.
Int. J. Pharm. 468(1-2) , 83-90, (2014) Gene therapy is a potent tool for the treatment of cancer and other gene defect diseases, which involves using DNA that encodes a functional, therapeutic gene to replace a mutated gene. However, the DNA transfection efficiency is restricted by its negative ch... |
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Small molecule inhibitors of the neuropilin-1 vascular endothelial growth factor A (VEGF-A) interaction.
J. Med. Chem. 53 , 2215-26, (2010) We report the molecular design and synthesis of EG00229, 2, the first small molecule ligand for the VEGF-A receptor neuropilin 1 (NRP1) and the structural characterization of NRP1-ligand complexes by NMR spectroscopy and X-ray crystallography. Mutagenesis stu... |
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Correlations of amyloid-β concentrations between CSF and plasma in acute Alzheimer mouse model.
Sci. Rep. 4 , 6777, (2014) Amyloid-β (Aβ) is one of the few neuropathological biomarkers associated with transporters of the blood-brain barrier (BBB). Despite the well-characterized clinical indication of decreasing Aβ levels in the cerebrospinal fluid (CSF) during the development of ... |
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Structure-activity relationships in ultrashort cationic lipopeptides: the effects of amino acid ring constraint on antibacterial activity.
Amino Acids 46(11) , 2517-30, (2014) Taking a minimalistic approach in efforts to lower the cost for the development of new synthetic antimicrobial peptides, ultrashort cationic lipopeptides were designed to mimic the amphiphilic nature crucial for their activity but with only a very short pepti... |
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What Goes around Comes around-A Comparative Study of the Influence of Chemical Modifications on the Antimicrobial Properties of Small Cyclic Peptides.
Pharmaceuticals (Basel.) 6 , 1130-44, (2013) Tryptophan and arginine-rich cyclic hexapeptides of the type cyclo-RRRWFW combine high antibacterial activity with rapid cell killing kinetics, but show low toxicity in human cell lines. The peptides fulfil the structural requirements for membrane interaction... |
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DOTA-functionalized polylysine: a high number of DOTA chelates positively influences the biodistribution of enzymatic conjugated anti-tumor antibody chCE7agl.
PLoS ONE 8 , e60350, (2013) Site-specific enzymatic reactions with microbial transglutaminase (mTGase) lead to a homogenous species of immunoconjugates with a defined ligand/antibody ratio. In the present study, we have investigated the influence of different numbers of 1,4,7,10-tetraaz... |