rifamycin B
rifamycin B structure
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Common Name | rifamycin B | ||
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| CAS Number | 13929-35-6 | Molecular Weight | 755.80500 | |
| Density | 1.37g/cm3 | Boiling Point | 907.1ºC at 760 mmHg | |
| Molecular Formula | C39H49NO14 | Melting Point | N/A | |
| MSDS | N/A | Flash Point | 502.4ºC | |
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Evidence for a multidrug resistance-associated protein 1 (MRP1)-related transport system in cultured rat liver biliary epithelial cells.
Life Sci. 64(9) , 763-74, (1999) Cellular accumulation and efflux of the anionic fluorescent dye carboxy-2',7'-dichlorofluorescein (CF) were studied in rat liver SDVI cells thought to derive from primitive bile ductules, in order to characterize carrier-related membrane transport of organic ... |
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Phase shifts in the stoichiometry of rifamycin B fermentation and correlation with the trends in the parameters measured online.
J. Biotechnol. 127(1) , 115-28, (2006) Antibiotic fermentation processes are raw material cost intensive and the profitability is greatly dependent on the product yield per unit substrate consumed. In order to reduce costs, industrial processes use organic nitrogen substrates (ONS) such as corn st... |
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Stereochemical assignment of intermediates in the rifamycin biosynthetic pathway by precursor-directed biosynthesis.
J. Am. Chem. Soc. 127(32) , 11202-3, (2005) Natural and semisynthetic rifamycins are clinically important inhibitors of bacterial DNA-dependent RNA polymerase. Although the polyketide-nonribosomal peptide origin of the naphthalene core of rifamycin B is well established, the absolute and relative confi... |
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Whole genome sequence of the rifamycin B-producing strain Amycolatopsis mediterranei S699.
J. Bacteriol. 193(19) , 5562-3, (2011) Amycolatopsis mediterranei S699 is an actinomycete that produces an important antibiotic, rifamycin B. Semisynthetic derivatives of rifamycin B are used for the treatment of tuberculosis, leprosy, and AIDS-related mycobacterial infections. Here, we report the... |
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Overproduction of rifamycin B by Amycolatopsis mediterranei and its relationship with the toxic effect of barbital on growth.
J. Antibiot. 51(1) , 58-63, (1998) A novel method for selecting overproducing strains of rifamycin B was developed. This technique involves the use of lysozyme and the effect of barbital on the growth of A. mediterranei. Complete medium added with glycine and barbital was inoculated with mutag... |
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Expression of the bacterial hemoglobin gene from Vitreoscilla stercoraria increases rifamycin B production in Amycolatopsis mediterranei.
J. Biosci. Bioeng. 106(5) , 493-7, (2008) It is well known that the culture for rifamycin B production by Amycolatopsis mediterranei requires high levels of dissolved oxygen, particularly in industrial processes. In this study, we report the construction of a vector for the expression of the bacteria... |
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A homologue of the Mycobacterium tuberculosis PapA5 protein, rif-orf20, is an acetyltransferase involved in the biosynthesis of antitubercular drug rifamycin B by Amycolatopsis mediterranei S699.
ChemBioChem. 6(5) , 834-7, (2005)
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Role of extracellular protease in nitrogen substrate management during antibiotic fermentation: a process model and experimental validation.
Appl. Microbiol. Biotechnol. 91(4) , 1019-28, (2011) Kinetics of extracellular protease (ECP) production has typically been studied for processes that involve protease as a product. We argue that ECP is equally important in fermentations where protease is not a product of interest. Industrial fermentations typi... |
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New insights into rifamycin B biosynthesis: isolation of proansamycin B and 34a-deoxy-rifamycin W as early macrocyclic intermediates indicating two separated biosynthetic pathways.
J. Antibiot. 55(4) , 396-406, (2002) Proansamycin B, the formerly postulated intermediate of rifamycin B biosynthesis, was isolated from cultures of the Amycolatopsis mediterranei mutant F1/24. The structure was determined using UV, IR, NMR and MS techniques. Biotransformation studies demonstrat... |
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Development of balanced medium composition for improved rifamycin B production by isolated Amycolatopsis sp. RSP-3.
Lett. Appl. Microbiol. 49(5) , 533-8, (2009) To develop optimum fermentation environment for enhanced rifamycin B production by isolated Amycolatopsis sp. RSP-3.The impact of different fermentation parameters on rifamycin B production by isolated Amycolatopsis sp. RSP-3 was investigated using Taguchi me... |