6-MPH4 DIHYDROCHLORIDE

6-MPH4 DIHYDROCHLORIDE Structure
6-MPH4 DIHYDROCHLORIDE structure
Common Name 6-MPH4 DIHYDROCHLORIDE
CAS Number 69113-63-9 Molecular Weight 254.11700
Density N/A Boiling Point 402.2ºC at 760 mmHg
Molecular Formula C7H13Cl2N5O Melting Point N/A
MSDS USA Flash Point 197ºC

Simple assay procedure for tyrosine hydroxylase activity by high-performance liquid chromatography employing coulometric detection with minimal sample preparation.

J. Chromatogr. A. 427 , 229, (1988)

A simple assay procedure for tyrosine hydroxylase activity in crude tissue samples was devised that requires minimal sample preparation and use of high-performance liquid chromatography with coulometric electrochemical detection. After incubation of enzyme sa...

A tyrosine hydroxylase assay in microwells using coupled nonenzymatic decarboxylation of dopa.

Anal. Biochem. 192 , 125, (1991)

A radiometric assay for tyrosine hydroxylase employing a coupled nonenzymatic decarboxylation of L-[14C]Dopa formed from L-[14C]tyrosine has been adapted for performance in a 96 microwell culture plate. The method uses an easily manufactured plate holder to c...

Melanogenesis inhibition by tetrahydropterines.

Biochim. Biophys. Acta 1794 , 1766-1774, (2009)

There is controversy in the literature concerning the action of tetrahydropterines on the enzyme tyrosinase and on melanogenesis in general. In this study, we demonstrate that tetrahydropterines can inhibit melanogenesis in several ways: i) by non-enzymatic i...

Analytical characterization of a sensitive radioassay for tyrosine hydroxylase activity in rodent striatum.

Neurochem. Res. 29 , 1467-1472, (2004)

Several buffer compositions with a wide range of pH values have been reported for radiometric assay of tyrosine hydroxylase (TH) in biological samples. Assay sensitivity becomes a prime concern while analyzing TH in minute samples like tissue biopsies or disc...

A unique dual activity amino acid hydroxylase in Toxoplasma gondii.

PLoS ONE 4 , e4801, (2009)

The genome of the protozoan parasite Toxoplasma gondii was found to contain two genes encoding tyrosine hydroxylase; that produces L-DOPA. The encoded enzymes metabolize phenylalanine as well as tyrosine with substrate preference for tyrosine. Thus the enzyme...