Astragaloside IV
Astragaloside IV structure
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Common Name | Astragaloside IV | ||
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| CAS Number | 84687-43-4 | Molecular Weight | 784.970 | |
| Density | 1.4±0.1 g/cm3 | Boiling Point | 895.7±65.0 °C at 760 mmHg | |
| Molecular Formula | C41H68O14 | Melting Point | 295-296ºC | |
| MSDS | Chinese USA | Flash Point | 495.5±34.3 °C | |
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[Protective effect and mechanism of astragaloside IV on oxidative stress injury of mesangial cells].
Zhongguo Zhong Yao Za Zhi 38(5) , 725-30, (2013) To study the protective effect of astragaloside IV (AS IV) on H2O2 induced human mesangial cells (HMC), and further explore its molecular mechanism.The cultured mesangial cells were divided into 5 groups: the normal control group, the H2O2 model group, the AS... |
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Astragaloside IV inhibited the activity of CYP1A2 in liver microsomes and influenced theophylline pharmacokinetics in rats.
J. Pharm. Pharmacol. 65(1) , 149-55, (2013) With the growing popularity of herbal and natural medicinal products, attention has turned to possible interactions between these products and pharmaceutical drugs. In this study, we examined whether astragaloside IV (AGS-IV) could inhibit the activity of CYP... |
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Astragaloside IV inhibits renal tubulointerstitial fibrosis by blocking TGF-β/Smad signaling pathway in vivo and in vitro.
Exp. Biol. Med. (Maywood.) 239(10) , 1310-24, (2014) Astragaloside IV (AS-IV) is a major active ingredient from Radix astragali, which has been considered as a renoprotective agent; however, its molecular mechanisms are unclear. Thus, we designed to investigate the renoprotective effects and mechanisms of AS-IV... |
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Can Hedysari Radix replace Astragali Radix in Danggui Buxue Tang, a Chinese herbal decoction for woman aliment?
Phytomedicine 20(12) , 1076-81, (2013) Astragali Radix (AR) has been used for over 2000 years in China for the enrichment of "Qi". Hedysari Radix (HR), a herb having similar chemical composition with AR, has been commonly used as a substitute of AR in herbal decoction. In order to evaluate the pos... |
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Astragaloside IV protects against focal cerebral ischemia/reperfusion injury correlating to suppression of neutrophils adhesion-related molecules.
Neurochem. Int. 60(5) , 458-65, (2012) Inflammation injury plays a key role in the process of cerebral injury induced by ischemia/reperfusion (I/R). Thus, we studied the potential of astragaloside IV, one of the major and active components of the astragalus membranaceous, to protect rat against ce... |
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The effect of Astragaloside IV on immune function of regulatory T cell mediated by high mobility group box 1 protein in vitro.
Fitoterapia 83(8) , 1514-22, (2012) High mobility group box 1 protein (HMGB1), a potent pro-inflammatory cytokine, contributes to the pathogenesis of diverse inflammatory and infectious disorders. Some studies have illustrated the potential effect of HMGB1 on regulatory T cells (Tregs). Astraga... |
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Pharmacological effects of Astragaloside IV: a literature review.
J. Tradit. Chin. Med. 33(3) , 413-6, (2013) To review the pharmacological effects and mechanisms of action of Astragaloside IV in Huangqi (Radix Astragali Mongolici).Aticles focusing on Astragaloside IV in English and Chinese in databases were collected and reviewed in order to summarize the latest ext... |
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Pro-angiogenic activity of astragaloside IV in HUVECs in vitro and zebrafish in vivo.
Mol. Med. Report. 5(3) , 805-11, (2012) Astragaloside IV (AS-IV) is a natural product isolated from the Chinese medical herb, Radix Astragali, which has been reported to be a potential candidate for treating diseases associated with abnormal angiogenesis; however, the effect of AS-IV on angiogenesi... |
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Astragaloside IV prevents MPP⁺-induced SH-SY5Y cell death via the inhibition of Bax-mediated pathways and ROS production.
Mol. Cell Biochem. 364(1-2) , 209-16, (2012) Parkinson's disease (PD) is characterized by a progressive degeneration of dopaminergic neurons in the substantia nigra. Oxidative stress and neural degeneration are suggested to be involved in the pathogenesis of PD. Previous studies have revealed that Astra... |
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The experimental study of Astragalus membranaceus on meridian tropsim: the distribution study of astragaloside IV in rat tissues.
J. Chromatogr. B. Analyt. Technol. Biomed. Life Sci. 911 , 71-5, (2012) According to Traditional Chinese Medicine (TCM) theories, TCM with different meridian tropism have different therapeutic effects. In view of the meridian tropism of Astragalus membranaceus (Huangqi), astragaloside IV, one of the effective phytochemicals of Hu... |