NALTRINDOLE ISOTHIOCYANATE
NALTRINDOLE ISOTHIOCYANATE structure
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Common Name | NALTRINDOLE ISOTHIOCYANATE | ||
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| CAS Number | 126876-64-0 | Molecular Weight | 471.57100 | |
| Density | 1.68g/cm3 | Boiling Point | 718.7ºC at 760mmHg | |
| Molecular Formula | C27H25N3O3S | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | 388.5ºC | |
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Alkylation of opioid receptors by 5'-naltrindole-isothiocyanate injected into the nucleus accumbens of rats: receptor selectivity and anatomical diffusion.
Synapse 60(5) , 384-91, (2006) Subtypes of the delta opioid receptor (Oprd1) have been suggested based on pharmacology studies. However, these subtypes have not been confirmed biochemically using either receptor binding assays or molecular cloning. Naltrindole-5'-isothiocyanate (5'-NTII) i... |
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Microinjection of the delta-opioid receptor selective antagonist naltrindole 5'-isothiocyanate site specifically affects cocaine self-administration in rats responding under a progressive ratio schedule of reinforcement.
Behav. Brain Res. 182(1) , 140-4, (2007) Whether the delta-opioid receptor (DOR) system can modulate behavioral effects of cocaine remains equivocal. We examined whether site- and subtype-selective blockade of DORs within the rat mesocorticolimbic system affects cocaine self-administration. The DOR ... |
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Evidence for chemical differentiation of delta opioid receptor subtypes by the sulfhydryl reagent N-ethylmaleimide.
Receptor 4(2) , 81-91, (1994) In this study, the delta receptor-selective nonequilibrium affinity ligands, 5'-NTII and DALCE, and the nonspecific sulfhydryl reagent NEM were evaluated over a range of concentrations and treatment conditions for their ability to selectively alter the bindin... |
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Differential antagonism by naltrindole-5'-isothiocyanate on [3H]DSLET and [3H]DPDPE binding to striatal slices of mice.
Life Sci. 53 , 1761-1765, (1993) Naltrindole-5'-isothiocyanate (5'-NTII), a nonequilibrium delta opioid receptor antagonist, has been shown to antagonize differentially the antinociception induced by DSLET without affecting that induced by DPDPE. In the present study, we investigated whether... |
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Role of spinal delta1 and delta2 opioid receptors in the antinociception produced by microinjection of L-glutamate in the ventromedial medulla of the rat.
Brain Res. 765(1) , 177-81, (1997) This study examined the contribution of spinal delta1 and delta2 opioid receptors to the antinociception produced by microinjection of L-glutamate in either the nucleus raphe magnus (NRM) or the nucleus reticularis gigantocellularis pars alpha (NGCp alpha) of... |
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Naltrindole 5'-isothiocyanate: a nonequilibrium, highly selective delta opioid receptor antagonist.
J. Med. Chem. 33(6) , 1547-8, (1990)
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Interaction of [D-Pen2,D-Pen5]enkephalin and [D-Ala2,Glu4]deltorphin with delta-opioid receptor subtypes in vivo.
Eur. J. Pharmacol. 252 , 133-137, (1994) The interaction of [D-Pen2,D-Pen5]enkephalin (DPDPE) and [D-Ala2,Glu4]deltorphin with delta-opioid receptor subtypes was investigated. Pretreatment of mice with the delta 1-opioid receptor antagonist, [D-Ala2,Leu5,Cys6]enkephalin (DALCE), produced a virtually... |
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Participation of delta opioid receptor subtypes in the stimulation of adenylyl cyclase activity in rat olfactory bulb.
J. Pharmacol. Exp. Ther. 275 , 1560-1567, (1995) A number of recent investigations have proposed the existence of two pharmacologically distinct delta opioid receptor subtypes, named delta 1 and delta 2. In the present study, we have investigated the involvement of the two delta receptors in the opioid stim... |
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Antagonism of delta(2)-opioid receptors by naltrindole-5'-isothiocyanate attenuates heroin self-administration but not antinociception in rats.
J. Pharmacol. Exp. Ther. 294 , 975-982, (2000) delta-Opioid receptors have been implicated in reinforcement processes and antagonists are available that produce long-lasting and selective antagonism of delta-opioid receptors in vivo. This experiment assessed the contribution of delta-opioid receptors to t... |
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Activation of G protein by opioid receptors: role of receptor number and G-protein concentration.
Eur. J. Pharmacol. 396 , 67-75, (2000) The collision-coupling model for receptor-G-protein interaction predicts that the rate of G-protein activation is dependent on receptor density, but not G-protein levels. C6 cells expressing mu- or delta-opioid receptors, or SH-SY5Y cells, were treated with b... |