6,7-Dichloro-1,4-dihydroquinoxaline-2,3-dione
6,7-Dichloro-1,4-dihydroquinoxaline-2,3-dione structure
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Common Name | 6,7-Dichloro-1,4-dihydroquinoxaline-2,3-dione | ||
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| CAS Number | 25983-13-5 | Molecular Weight | 231.036 | |
| Density | 1.6±0.1 g/cm3 | Boiling Point | 523.4ºC at 760 mmHg | |
| Molecular Formula | C8H4Cl2N2O2 | Melting Point | N/A | |
| MSDS | USA | Flash Point | 270.3ºC | |
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Novel NMDA/glycine site antagonists attenuate cocaine-induced behavioral toxicity.
Eur. J. Pharmacol. 338 , 233-242, (1997) N-Methyl-D-aspartate (NMDA)/glycine site antagonists were tested for their ability to prevent cocaine-induced convulsions and lethality in Swiss Webster mice. Pre-treatment of mice with the novel NMDA/glycine site antagonists ACEA-1021 (5-nitro-6,7-dichloro-1... |
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6,7-Dichloroquinoxaline-2,3-dione is a competitive antagonist specific to strychnine-insensitive [3H]glycine binding sites on the N-methyl-D-aspartate receptor complex.
J. Neurochem. 54 , 699-702, (1990) Multiple binding sites on the N-methyl-D-aspartate (NMDA) receptor complex were examined using rat brain synaptic membranes treated with Triton X-100. Binding of [3H](+)-5-methyl-10,11-dihydro-5H-dibenzo[a,d]cyclohepten-5,10-imi ne ([3H]MK-801), a noncompetit... |
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