Bergamotine
Bergamotine structure
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Common Name | Bergamotine | ||
|---|---|---|---|---|
| CAS Number | 7380-40-7 | Molecular Weight | 338.397 | |
| Density | 1.2±0.1 g/cm3 | Boiling Point | 503.7±50.0 °C at 760 mmHg | |
| Molecular Formula | C21H22O4 | Melting Point | 75-80ºC | |
| MSDS | Chinese USA | Flash Point | 258.4±30.1 °C | |
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Grapefruit (Citrus paradisi Macfad) phytochemicals composition is modulated by household processing techniques.
J. Food Sci. 77(9) , C921-6, (2012) Grapefruits (Citrus paradisi Macfad) contain several phytochemicals known to have health maintaining properties. Due to the consumer's interest in obtaining high levels of these phytochemicals, it is important to understand the changes in their levels by comm... |
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Structure-activity relationships for naturally occurring coumarins as β-secretase inhibitor.
Bioorg. Med. Chem. 20 , 784-8, (2012) The present study was demonstrated to evaluate the effects of naturally occurring coumarins (NOCs) including simple coumarins, furanocoumarins, and pyranocoumarins on the inhibition of β-secretase (BACE1) activity. Of 41 NOCs examined, some furanocoumarins in... |
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Chemical composition of hexane extract of Citrus aurantifolia and anti-Mycobacterium tuberculosis activity of some of its constituents.
Molecules 17(9) , 11173-84, (2012) The main aim of this study was to isolate and characterize the active compounds from the hexane extract of the fruit peels of Citrus aurantiifolia, which showed activity against one sensitive and three monoresistant (isoniazid, streptomycin or ethambutol) str... |
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A quantitative high-throughput 96-well plate fluorescence assay for mechanism-based inactivators of cytochromes P450 exemplified using CYP2B6.
Nat. Protoc. 5(10) , 1652-8, (2010) Mechanism-based inactivators such as bergamottin are useful chemical tools for identifying the functions of specific active-site amino acid residues in the reactions catalyzed by cytochromes P450 (CYPs or P450s), which are responsible for the metabolism of a ... |
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The use of heat treatment to eliminate drug interactions due to grapefruit juice.
Biol. Pharm. Bull. 29(11) , 2274-8, (2006) Grapefruit juice (GJ) contains components that may increase the bioavailability of drugs; however, approaches to the removal of these components have been little investigated. It is known that furanocoumarin derivatives (FCs), such as bergamottin (BG) and 6',... |
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Design, synthesis and evaluation of furanocoumarin monomers as inhibitors of CYP3A4.
Org. Biomol. Chem. 4(8) , 1604-10, (2006) A number of furanocoumarins isolated from grapefruit juice have been found to inhibit CYP3A4 activity in vitro. In this study, we have designed and synthesised a range of analogues based on bergamottin to investigate the relationship between chemical structur... |
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Coumarins are competitive inhibitors of cytochrome P450 1B1, with equal potency for allelic variants.
Pharmacogenet. Genomics 15(3) , 183-8, (2005) Coumarins are naturally occurring chemicals with potential as chemopreventive agents, several with known action on the cytochrome P450 1A family. We examined whether cytochrome P450 1B1 (CYP1B1) was inhibited by coumarins, whether such inhibition was competit... |
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Effect of maturity, processing, and storage on the furanocoumarin composition of grapefruit and grapefruit juice.
J. Food Sci. 76(4) , C543-8, (2011) Since the early 1990's, grapefruit juice has been implicated in drug interaction with various furanocoumarins (FCs) now associated with the effect. Although FCs are present in various fruits and vegetables, it is their presence in grapefruit that has attracte... |
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Aspergillus niger metabolism of citrus furanocoumarin inhibitors of human cytochrome P450 3A4.
Appl. Microbiol. Biotechnol. 78(2) , 343-9, (2008) Fungi metabolize polycyclic aromatic hydrocarbons by a number of detoxification processes, including the formation of sulfated and glycosidated conjugates. A class of aromatic compounds in grapefruit is the furanocoumarins (FCs), and their metabolism in human... |
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Construction of a model to estimate the CYP3A inhibitory effect of grapefruit juice.
Pharmazie 66(7) , 525-8, (2011) Grapefruit juice (GFJ) is known to affect the pharmacokinetics of a variety of drugs administered concomitantly and this is due to inhibition of intestinal CYP3A, a barrier protein for drug absorption. Some compounds such as furanocoumarin derivatives have be... |