PGLa
PGLa structure
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Common Name | PGLa | ||
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| CAS Number | 102068-15-5 | Molecular Weight | 1968.45000 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C88H162N26O22S | Melting Point | N/A | |
| MSDS | USA | Flash Point | N/A | |
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Synergistic transmembrane insertion of the heterodimeric PGLa/magainin 2 complex studied by solid-state NMR.
Biochim. Biophys. Acta 1788 , 1667-1679, (2009) The skin secretions of amphibians are a rich source of antimicrobial peptides. The two antimicrobial peptides PGLa and magainin 2, isolated from the African frog Xenopus laevis, have been shown to act synergistically by permeabilizing the membranes of microor... |
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Synergistic insertion of antimicrobial magainin-family peptides in membranes depends on the lipid spontaneous curvature.
Biophys. J. 104(6) , L9-11, (2013) PGLa and magainin 2 (MAG2) are amphiphilic antimicrobial peptides from frog skin with known synergistic activity. The orientation of the two helices in membranes was studied using solid-state (15)N-NMR, for each peptide alone and for a 1:1 mixture of the pept... |
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Rapid-prototyped and salt-leached PLGA scaffolds condition cell morpho-functional behavior.
J. Biomed. Mater. Res. A 85(2) , 466-76, (2008) Three dimensional scaffolds microfabricated using pressure-assisted microsyringe (PAM) with controlled geometry and porous membranes obtained using salt leaching were both tested with three different cell types to identify an optimal microstructural architect... |
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A single centre study of coil embolization of intracranial aneurysms comparing bare platinum and PGLA-coated coils.
J. Clin. Neurosci. 19(2) , 271-6, (2012) There is no robust consensus on the efficacy of polyglycolic/polylactic acid (PGLA)-coated coils used in the endovascular embolization of intracranial aneurysms. We present a comparative study of bare platinum coils and PGLA-coated Gugliemi Detachable Coils (... |
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Gd-DTPA-loaded PLGA microbubbles as both ultrasound contrast agent and MRI contrast agent--a feasibility research.
J. Biomed. Mater. Res. B. Appl. Biomater. 93(2) , 551-6, (2010) To prepare the Gd-DTPA-loaded poly (lactic-co-glycolic acid) (PLGA) microbubbles for both ultrasound imaging and MRI imaging.Biodegradable high-molecular-weight poly (lactic-co-glycolic acid) (PLGA) was used as an encapsulating vehicle to fabricate a contrast... |
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Embolization of intracranial aneurysms with second-generation Matrix-2 detachable coils: mid-term and long-term results.
J. Neurointerv. Surg. 3(4) , 324-30, (2011) Bioactive polyglycolic/polylactic acid (PGLA)-coated Matrix detachable coils were reported to incite intra-aneurysmal inflammation and fibrosis. Multiple large case series with Matrix-1 coils have shown no advantage with respect to aneurysm recurrence. Second... |
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Isolation and characterisation of a new antimicrobial peptide from the skin of Xenopus laevis.
Int. J. Antimicrob. Agents 38(6) , 510-5, (2011) A new antimicrobial peptide (AMP) named PGLa-H has been isolated from the skin of the African clawed frog (Xenopus laevis) using gel filtration and reverse-phase high-performance liquid chromatography (RP-HPLC). Its amino acid sequence was determined as KIAKV... |
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Biological activity and structural aspects of PGLa interaction with membrane mimetic systems.
Biochim. Biophys. Acta 1788(8) , 1656-66, (2009) Peptidyl-glycine-leucine-carboxyamide (PGLa), isolated from granular skin glands of Xenopus laevis, is practically devoid of secondary structure in aqueous solution and in the presence of zwitterionic phospholipids, when added exogenously, but adopts an alpha... |
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USP apparatus 4 method for in vitro release testing of protein loaded microspheres.
Int. J. Pharm. 409(1-2) , 178-84, (2011) The objective was to develop an in vitro release method for protein loaded poly(lactide-co-glycolide) (PLGA) microspheres. A modified USP apparatus 4 and sample and separate methods were compared using a microsphere formulation encapsulating a model protein, ... |
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Controllable dual-release of dexamethasone and bovine serum albumin from PLGA/β-tricalcium phosphate composite scaffolds.
J. Biomed. Mater. Res. B. Appl. Biomater. 96(1) , 139-51, (2011) Localized dual-drug delivery from biodegradable scaffolds is an important strategy in tissue engineering. In this study, porous poly(L-lactide-co-glycolide) (PLGA)/β-tricalcium phosphate scaffolds containing both dexamethasone (Dex) and bovine serum albumin (... |