Secoisolariciresinol
Secoisolariciresinol structure
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Common Name | Secoisolariciresinol | ||
|---|---|---|---|---|
| CAS Number | 29388-59-8 | Molecular Weight | 362.417 | |
| Density | 1.3±0.1 g/cm3 | Boiling Point | 609.1±55.0 °C at 760 mmHg | |
| Molecular Formula | C20H26O6 | Melting Point | 112-114ºC | |
| MSDS | Chinese USA | Flash Point | 322.1±31.5 °C | |
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Cytotoxic and HIF-1alpha inhibitory compounds from Crossosoma bigelovii.
J. Nat. Prod. 72(5) , 805-12, (2009) Cytotoxicity-guided fractionation of an organic solvent extract of the plant Crossosoma bigelovii led to the discovery of a new strophanthidin glycoside (1) and two new 2-methylchromone glycosides (2 and 3). Also isolated were the known chromones eugenin and ... |
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Role of bifidobacteria in the activation of the lignan secoisolariciresinol diglucoside.
Appl. Microbiol. Biotechnol. 92 , 159-168, (2011) Lignans are ubiquitous plant polyphenols, which have relevant health properties being the major phytoestrogens occurring in Western diets. Secoisolariciresinol (SECO) is the major dietary lignan mostly found in plants as secoisolariciresinol diglucoside (SDG)... |
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Production of secoisolariciresinol from defatted flaxseed by bacterial biotransformation.
J. Appl. Microbiol. 113(6) , 1352-61, (2012) Secoisolariciresinol (SECO) is increasingly recognized for potential clinical application because of its preventive effects against breast and colon cancers, atherosclerosis and diabetes, and its production through biotransformation has been attempted. Howeve... |
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Estradiol-17beta and linseed meal interact to alter visceral organ mass and hormone concentrations from ovariectomized ewes.
Domest. Anim. Endocrinol. 37(3) , 148-58, (2009) To evaluate the estrogenic potential of secoisolariciresinol diglycoside (SDG) found in linseed meal (LSM) on visceral organ mass, IGF-I, and thyroid hormone (T(3) and T(4)) concentrations, 48 multiparous, ovariectomized ewes (54.6 +/- 1.1 kg) were used in a ... |
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Reduction in Ki-67 in benign breast tissue of high-risk women with the lignan secoisolariciresinol diglycoside.
Cancer Prev. Res. (Phila.) 3(10) , 1342-50, (2010) Preclinical and correlative studies suggest reduced breast cancer with higher lignan intake or blood levels. We conducted a pilot study of modulation of risk biomarkers for breast cancer in premenopausal women after administration of the plant lignan secoisol... |
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(-)-Secoisolariciresinol attenuates high-fat diet-induced obesity in C57BL/6 mice.
Food Funct. 3(1) , 76-82, (2012) Flaxseed lignan, secoisolariciresinol has been reported to possess health benefits. We previously synthesized each stereoisomer of secoisolariciresinol and found that (-)-secoisolariciresinol reduces lipid accumulation and induces adiponectin production in 3T... |
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Development of antibodies against secoisolariciresinol--application to the immunolocalization of lignans in Linum usitatissimum seeds.
Phytochemistry 71(17-18) , 1979-87, (2010) Lignans are widely distributed plant metabolites associated with a large range of biological activities. In order to gain insight into their biosynthesis and their spatio-temporal accumulation an immunological probe was developed. Secondary metabolites genera... |
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Neural cell activation by phenolic compounds from the Siberian larch (Larix sibirica).
J. Nat. Prod. 77(7) , 1554-61, (2014) Small organic phenolic compounds from natural sources have attracted increasing attention due to their potential to ameliorate the serious consequences of acute and chronic traumata of the mammalian nervous system. In this contribution, it is reported that ph... |
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Antiproliferative activity of lignans against the breast carcinoma cell lines MCF 7 and BT 20.
Arch. Gynecol. Obstet. 285(4) , 1145-51, (2012) Phytoestrogens are plant-derived, non-steroidal phytochemicals with anticarcinogenic potential. The major structural classes are the isoflavones and lignans. The aim of this study was to compare the effect of the plant-derived lignans secoisolariciresinol and... |
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The antidepressant effect of secoisolariciresinol, a lignan-type phytoestrogen constituent of flaxseed, on ovariectomized mice.
J. Nat. Med. 67(1) , 222-7, (2013) Secoisolariciresinol (SECO) is a natural lignan-type phytoestrogen constituent mainly found in flaxseed. It can be metabolized in vivo to mammalian lignans of enterodiol and enterolactone, which have been proven to be effective in relieving menopausal syndrom... |