TC-H 106
TC-H 106 structure
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Common Name | TC-H 106 | ||
|---|---|---|---|---|
| CAS Number | 937039-45-7 | Molecular Weight | 339.431 | |
| Density | 1.2±0.1 g/cm3 | Boiling Point | 627.3±45.0 °C at 760 mmHg | |
| Molecular Formula | C20H25N3O2 | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | 333.1±28.7 °C | |
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Evaluation of histone deacetylase inhibitors (HDACi) as therapeutic leads for human African trypanosomiasis (HAT).
Bioorg. Med. Chem. 23 , 5151-5, (2015) Two of the histone deacetylases, TbDAC1 and TbDAC3, have been reported to be essential genes in trypanosomes. Therefore, we tested the activity of a panel of human histone deacetylase inhibitors (HDACi) for their ability to block proliferation of Trypanosoma ... |
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Inhibition of Histone Deacetylases Permits Lipopolysaccharide-Mediated Secretion of Bioactive IL-1β via a Caspase-1-Independent Mechanism.
J. Immunol. 195 , 5421-31, (2015) Histone deacetylase (HDAC) inhibitors (HDACi) are clinically approved anticancer drugs that have important immune-modulatory properties. We report the surprising finding that HDACi promote LPS-induced IL-1β processing and secretion in human and murine dendrit... |
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