diminazene aceturate
diminazene aceturate structure
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Common Name | diminazene aceturate | ||
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| CAS Number | 908-54-3 | Molecular Weight | 515.52200 | |
| Density | N/A | Boiling Point | 463.3ºC at 760mmHg | |
| Molecular Formula | C22H29N9O6 | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | 234ºC | |
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A validated and stability indicating HPLC method for analysis of diminazene aceturate and antipyrine combination in a ready injectable solution.
Drug Res. (Stuttg.) 63(6) , 300-4, (2013) Diminazene aceturate and Antipyrine combination therapy is widely used in veterinary medicine. A simple reverse HPLC method for the analysis of samples of a ready injectable formulation containing a mixture of active ingredients and inactive excipients has be... |
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A sensitive and reproducible in vivo imaging mouse model for evaluation of drugs against late-stage human African trypanosomiasis.
J. Antimicrob. Chemother. 70(2) , 510-7, (2015) To optimize the Trypanosoma brucei brucei GVR35 VSL-2 bioluminescent strain as an innovative drug evaluation model for late-stage human African trypanosomiasis.An IVIS® Lumina II imaging system was used to detect bioluminescent T. b. brucei GVR35 parasites in... |
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Inhibition of spermidine/spermine N1-acetyltransferase activity: a new therapeutic concept in rheumatoid arthritis.
Arthritis Rheumatology 66(7) , 1723-33, (2014) Changes in polyamine-modulated factor 1 (PMF-1) promoter methylation might favor the expression of spermidine/spermine N1-acetyltransferase 1 (SSAT-1), causing excessive consumption of S-adenosyl methionine (SAM). This study was undertaken to evaluate the eff... |
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Analysis of energy generation and glycolysis pathway in diminazene aceturate-resistant Babesia gibsoni isolate in vitro.
Jpn. J. Vet. Res. 60(2-3) , 51-61, (2012) In our previous study, the level of parasitemia of the diminazene aceturate (DA)-resistant B. gibsoni isolate was continuously lower than that of the wild-type, indicating the possible alteration of energy metabolism in that isolate. Therefore, in the present... |
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Profiling the anti-protozoal activity of anti-cancer HDAC inhibitors against Plasmodium and Trypanosoma parasites.
Int. J. Parasitol. Drugs Drug Resist. 5 , 117-26, (2015) Histone deacetylase (HDAC) enzymes work together with histone acetyltransferases (HATs) to reversibly acetylate both histone and non-histone proteins. As a result, these enzymes are involved in regulating chromatin structure and gene expression as well as oth... |
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Evaluation of a fluorescence-based method for antibabesial drug screening.
Antimicrob. Agents Chemother. 58(8) , 4713-7, (2014) In vitro evaluation of chemotherapeutic agents against Babesia and Theileria parasites has become routine, and the effectiveness of these chemicals is usually determined by comparing the parasitemia dynamics of untreated and treated parasites. Although micros... |
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Evaluation of in vitro and in vivo inhibitory effects of fusidic acid on Babesia and Theileria parasites.
Vet. Parasitol. 191(1-2) , 1-10, (2013) Fusidic acid known to has antibacterial, antifungal, and antimalarial activities. Fusidic acid blocks translation elongation factor G gene in Plasmodium falciparum. In the present study, the inhibitory effects of fusidic acid on the in vitro growth of bovine ... |
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Antiglaucomatous effects of the activation of intrinsic Angiotensin-converting enzyme 2.
Invest. Ophthalmol. Vis. Sci. 54(6) , 4296-306, (2013) To evaluate the effects of the activation of endogenous angiotensin-converting enzyme 2 (ACE2) using the compound diminazene aceturate (DIZE) in an experimental model of glaucoma in Wistar rats.DIZE (1 mg/kg) was administered daily, either systemically or top... |
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Crovirin, a snake venom cysteine-rich secretory protein (CRISP) with promising activity against Trypanosomes and Leishmania.
PLoS Negl. Trop. Dis. 8(10) , e3252, (2014) The neglected human diseases caused by trypanosomatids are currently treated with toxic therapy with limited efficacy. In search for novel anti-trypanosomatid agents, we showed previously that the Crotalus viridis viridis (Cvv) snake venom was active against ... |
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Field detection of resistance to isometamidium chloride and diminazene aceturate inTrypanosoma vivaxfrom the region of the Boucle du Mouhoun in Burkina Faso
Vet. Parasitol. 187(1-2) , 105-11, (2012) A longitudinal study assessed the chemoresistance to isometamidium chloride (ISM) and diminazene aceturate (DA) in the region of the Boucle du Mouhoun in Burkina Faso. A preliminary cross-sectional survey allowed the identification of the 10 villages with the... |