Phenamil methanesulfonate
Phenamil methanesulfonate structure
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Common Name | Phenamil methanesulfonate | ||
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| CAS Number | 1161-94-0 | Molecular Weight | 401.829 | |
| Density | N/A | Boiling Point | 621.7ºC at 760 mmHg | |
| Molecular Formula | C13H16ClN7O4S | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | 329.8ºC | |
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The lung amiloride-sensitive Na+ channel: biophysical properties, pharmacology, ontogenesis, and molecular cloning.
Proc. Natl. Acad. Sci. U. S. A. 91 , 247, (1994) Water balance in the lung is controlled via active Na+ and Cl- transport. Electrophysiological measurements on lung epithelial cells demonstrated the presence of a Na+ channel that is inhibited by amiloride (K0.5 = 90 nM) and some of its derivatives such as p... |
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Phenamil: an irreversible inhibitor of sodium channels in the toad urinary bladder.
J. Membr. Biol. 87 , 45, (1985) Several new amiloride analogues and two reported photoaffinity analogues were tested for irreversible inhibition of short-circuit current, Isc, in toad bladder. Bromoamiloride, a photoaffinity analogue, induced 40% irreversible inhibition at 500 microM after ... |
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Biochemical identification of two types of phenamil binding sites associated with amiloride-sensitive Na+ channels.
Biochemistry 28 , 3744, (1989) The existence of distinct forms of the epithelium Na+ channel that differ in their sensitivity to amiloride has been repeatedly suggested by physiological data. The biochemical basis for these differences was analyzed by using phenamil, the most potent inhibi... |