7H-Dibenzo[c,g]carbazole
![7H-Dibenzo[c,g]carbazole Structure](https://image.chemsrc.com/caspic/202/194-59-2.png)
7H-Dibenzo[c,g]carbazole structure
|
Common Name | 7H-Dibenzo[c,g]carbazole | ||
|---|---|---|---|---|
| CAS Number | 194-59-2 | Molecular Weight | 267.324 | |
| Density | 1.3±0.1 g/cm3 | Boiling Point | 544.1±19.0 °C at 760 mmHg | |
| Molecular Formula | C20H13N | Melting Point | 152-154ºC | |
| MSDS | N/A | Flash Point | 246.5±14.1 °C | |
|
Polycyclic aromatic hydrocarbons: 15 Listings - benz[a]anthracene, benzo[b]fluoranthene, benzo[j]fluoranthene, benzo[k]fluoranthene, benzo[a]pyrene, dibenz[a,h]acridine, dibenz[a,j]acridine, dibenz[a,h]anthracene, 7H-dibenzo[c,g]carbazole, dibenzo[a,e]pyrene, dibenzo[a,h]pyrene, dibenzo[a,i]pyrene, dibenzo[a,l]pyrene, indeno[1,2,3-cd]pyrene, 5-methylchrysene.
Rep. Carcinog. 12 , 353-61, (2011)
|
|
|
Sustained induction of cytochrome P4501A1 in human hepatoma cells by co-exposure to benzo[a]pyrene and 7H-dibenzo[c,g]carbazole underlies the synergistic effects on DNA adduct formation.
Toxicol. Appl. Pharmacol. 271(1) , 1-12, (2013) To gain a deeper insight into the potential interactions between individual aromatic hydrocarbons in a mixture, several benzo[a]pyrene (B[a]P) and 7H-dibenzo[c,g]carbazole (DBC) binary mixtures were studied. The biological activity of the binary mixtures was ... |
|
|
Tissue-specific activities of methylated dibenzo[c,g]carbazoles in mice: carcinogenicity, DNA adduct formation, and CYP1A induction in liver and skin.
Environ. Mol. Mutagen. 35(2) , 139-49, (2000) The potent multitissue carcinogen 7H-dibenzo[c,g]carbazole and nine methylated derivatives, synthesized on the basis of the positions in the parent compound that are involved in metabolism, were tested for their ability to induce sarcomas and hepatic tumors i... |
|
|
In vitro toxicity of 7H-dibenzo[c,g]carbazole in human liver cell lines.
Toxicol. In Vitro 16(3) , 235-43, (2002) 7H-Dibenzo[c,g]carbazole (DBC) is a model N-heterocyclic aromatic compound (NHA) which is both a hepatotoxin and hepatocarcinogen in rodents. The focus of this investigation was to determine whether human liver cell lines display differential sensitivities to... |
|
|
Genotoxicity of 7H-dibenzo[c,g]carbazole and its tissue-specific derivatives in human hepatoma HepG2 cells is related to CYP1A1/1A2 expression.
Environ. Mol. Mutagen. 52(8) , 636-45, (2011) The goal of this study was to investigate the genotoxicity of 7H-dibenzo[c,g]carbazole (DBC), a ubiquitous environmental pollutant, and its methyl derivatives, 5,9-dimethylDBC (DiMeDBC), a strict hepatocarcinogen, and N-methylDBC (N-MeDBC), a specific sarcoma... |
|
|
Frequent Ha-ras mutations in murine skin and liver tumors induced by 7H-dibenzo[c,g]carbazole.
Mol. Carcinog. 25(2) , 107-12, (1999) 7H-dibenzo[c,g]carbazole (DBC) is a potent liver and skin carcinogen when topically applied to the back skin of mice. This compound is found in complex mixtures produced during incomplete combustion of fossil fuels as well as in wood and tobacco smoke. The ob... |
|
|
Comparison of Ha-ras mutational spectra of N-methyldibenzo[c,g]carbazole and 7H-dibenzo[c,g]carbazole-induced mouse skin tumors.
Mol. Carcinog. 32(2) , 55-60, (2001) Carcinogenic N-heterocyclic aromatic hydrocarbons are formed during the incomplete combustion of fossil fuels as well as cigarette smoke. N-Methyldibenzo[c,g]carbazole (NMeDBC) and 7H-dibenzo[c,g]carbazole (DBC) are members of this group. DBC induces mouse sk... |
|
|
Genotoxicity of 7H-dibenzo[c,g]carbazole and its methyl derivatives in human keratinocytes.
Mutat. Res. 743(1-2) , 91-8, (2012) Differences between tissues in the expression of drug-metabolizing enzymes may substantially contribute to tissue-specificity of chemical carcinogens. To verify this hypothesis, the spontaneously immortalized human keratinocytes HaCaT were used, in order to e... |
|
|
Histopathological and molecular changes during apoptosis produced by 7H-dibenzo[c,g]-carbazole in mouse liver.
Toxicol. Pathol. 32(2) , 202-11, (2004) The topical administration of 7H-dibenzo[c,g]carbazole (7H-DBC) at very low but repeated doses causes genotoxic effects such as DNA adduct formation and produces hepatocellular apoptosis in mouse liver. The purpose of this work was to investigate the alterati... |
|
|
Induction of DNA synthesis in mouse liver following increases of DNA adduct levels elicited by very low cumulative doses of the genotoxic hepatocarcinogen 7H-dibenzo[c,g]carbazole.
Toxicol. Pathol. 29(5) , 528-34, (2001) The purpose of this work was to investigate the administration of very low but repeated doses of a genotoxic carcinogen and an eventual correlation with cellular DNA synthesis. The compound 7H-dibenzo[c,g]carbazole is a genotoxic carcinogen in the mouse liver... |