Z-Val-Phe-OH
Z-Val-Phe-OH structure
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Common Name | Z-Val-Phe-OH | ||
|---|---|---|---|---|
| CAS Number | 19542-51-9 | Molecular Weight | 398.45200 | |
| Density | 1.211 g/cm3 | Boiling Point | 648.6ºC at 760 mmHg | |
| Molecular Formula | C22H26N2O5 | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | 346.1ºC | |
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Inhibition of calpain is a component of nitric oxide-induced down-regulation of human mast cell adhesion.
J. Immunol. 170(1) , 287-93, (2003) Nitric oxide is an important messenger that regulates mast cell activity by modifications to gene expression and intracellular pathways associated with exocytosis and adhesion. Integrin interactions with extracellular matrix components modulate an array of ce... |
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Calpain mediates ischemic injury of the liver through modulation of apoptosis and necrosis.
Gastroenterology 116(1) , 168-78, (1999) Calpain proteases have been implicated in cell death by necrosis and more recently by apoptosis. Experiments were designed to determine the role of calpain proteases in ischemic rat liver injury by measurement of cytosolic calpain activity after different per... |
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Calpain inhibition prevents sinusoidal endothelial cell apoptosis in the cold ischemic rat liver.
Transplantation 68(1) , 136-40, (1999) Cold preservation of the liver followed by reperfusion results in sinusoidal endothelial cell (SEC) apoptosis. Calpain-like activity is dramatically increased during reperfusion and inhibition of calpains results in lower graft injury and longer survival. Rec... |
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The role of cysteine proteases in hypoxia-induced rat renal proximal tubular injury.
Proc. Natl. Acad. Sci. U. S. A. 92(17) , 7662-6, (1995) The role of the lysosomal proteases cathepsins B and L and the calcium-dependent cytosolic protease calpain in hypoxia-induced renal proximal tubular injury was investigated. As compared to normoxic tubules, cathepsin B and L activity, evaluated by the specif... |
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Dysregulation of the calpain-calpastatin system plays a role in the development of cerulein-induced acute pancreatitis in the rat.
Am. J. Physiol. Gastrointest. Liver Physiol. 286(6) , G932-41, (2004) Calpain, a calcium-dependent cytosolic cysteine protease, is implicated in a multitude of cellular functions but also plays a role in cell death. Recently, we have shown that two ubiquitous isoforms, termed micro-calpain and m-calpain, are expressed in rat pa... |
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Calpain-mediated breakdown of cytoskeletal proteins contributes to cholecystokinin-induced damage of rat pancreatic acini.
Int. J. Exp. Pathol. 90(4) , 387-99, (2009) The cytosolic cysteine protease calpain is implicated in a multitude of cellular functions but also plays a role in cell damage. Our previous results suggest that an activation of calpain accompanied by a decrease in its endogenous inhibitor calpastatin may c... |