CYCLOHEXANAMINIUM ((2R,3S,4R,5R)-5-(6-AMINO-9H-PURIN-9-YL)-3,4-DIHYDROXYTETRAHYDROFURAN-2-YL)METHYL HYDROGENDIPHOSPHATE
CYCLOHEXANAMINIUM ((2R,3S,4R,5R)-5-(6-AMINO-9H-PURIN-9-YL)-3,4-DIHYDROXYTETRAHYDROFURAN-2-YL)METHYL HYDROGENDIPHOSPHATE structure
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Common Name | CYCLOHEXANAMINIUM ((2R,3S,4R,5R)-5-(6-AMINO-9H-PURIN-9-YL)-3,4-DIHYDROXYTETRAHYDROFURAN-2-YL)METHYL HYDROGENDIPHOSPHATE | ||
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| CAS Number | 102029-87-8 | Molecular Weight | 625.54900 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C22H41N7O10P2 | Melting Point | N/A | |
| MSDS | USA | Flash Point | N/A | |
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Adenosine derived from ADP can contribute to inhibition of platelet aggregation in the presence of a P2Y12 antagonist.
Arterioscler. Thromb. Vasc. Biol. 31 , 416-422, (2011) To investigate whether adenosine diphosphate (ADP)-derived adenosine might inhibit platelet aggregation, especially in the presence of a P2Y₁₂ antagonist, where the effects of ADP at the P2Y₁₂ receptor would be prevented.Platelet aggregation was measured in r... |
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Extracellular Ca(2+) modulates ADP-evoked aggregation through altered agonist degradation: implications for conditions used to study P2Y receptor activation.
Br. J. Haematol. 153 , 83-91, (2011) ADP is considered a weak platelet agonist due to the limited aggregation responses it induces in vitro at physiological concentrations of extracellular Ca(2+) [(Ca(2+) )(o) ]. Lowering [Ca(2+) ](o) paradoxically enhances ADP-evoked aggregation, an effect that... |
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P2Y receptors in health and disease.
Adv. Pharmacol. 61 , 417-439, (2011) The purine- and pyrimidine-sensitive P2Y receptors belong to the large group of G-protein-coupled receptors that are the target of approximately one-third of the pharmaceutical drugs used in the clinic today. It is therefore not unexpected that the P2Y recept... |
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P2 receptors and platelet function.
Purinergic Signal. 7(3) , 293-303, (2011) Following vessel wall injury, platelets adhere to the exposed subendothelium, become activated and release mediators such as TXA(2) and nucleotides stored at very high concentration in the so-called dense granules. Released nucleotides and other soluble agent... |