Metolazone
Metolazone structure
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Common Name | Metolazone | ||
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| CAS Number | 17560-51-9 | Molecular Weight | 365.835 | |
| Density | 1.4±0.1 g/cm3 | Boiling Point | 613.6±65.0 °C at 760 mmHg | |
| Molecular Formula | C16H16ClN3O3S | Melting Point | 252-254°C | |
| MSDS | Chinese USA | Flash Point | 324.9±34.3 °C | |
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Simultaneous determination of metolazone and losartan potassium in their binary mixtures using high-performance liquid chromatography with fluorimetric detection: application to combined tablets and spiked human plasma.
Luminescence 29(5) , 462-70, (2014) A new, specific and sensitive reversed-phase high-performance liquid chromatography method was developed for the simultaneous determination of metolazone (MET) and losartan potassium (LOS). Good chromatographic separation was achieved within 6.0 min on a 150 ... |
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Ultra high performance supercritical fluid chromatography coupled with tandem mass spectrometry for screening of doping agents. I: Investigation of mobile phase and MS conditions.
Anal. Chim. Acta 853 , 637-46, (2014) The conditions for the analysis of selected doping substances by UHPSFC-MS/MS were optimized to ensure suitable peak shapes and maximized MS responses. A representative mixture of 31 acidic and basic doping agents was analyzed, in both ESI+ and ESI- modes. Th... |
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[Renal effect of treatment for heart failure].
Ugeskr. Laeg. 171(9) , 718, (2009) The case of a 66-year-old male with heart failure and cardiorenal syndrome is presented. The patient had normal renal function before intensive treatment with diuretics and ACE inhibitor. Shortly after the ACE inhibitor was stopped and diuretics were either s... |
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Ultra high performance supercritical fluid chromatography coupled with tandem mass spectrometry for screening of doping agents. II: Analysis of biological samples.
Anal. Chim. Acta 853 , 647-59, (2014) The potential and applicability of UHPSFC-MS/MS for anti-doping screening in urine samples were tested for the first time. For this purpose, a group of 110 doping agents with diverse physicochemical properties was analyzed using two separation techniques, nam... |
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Thiazide-like diuretic drug metolazone activates human pregnane X receptor to induce cytochrome 3A4 and multidrug-resistance protein 1.
Biochem. Pharmacol. 92(2) , 389-402, (2014) Human pregnane X receptor (hPXR) regulates the expression of drug-metabolizing enzyme cytochrome P450 3A4 (CYP3A4) and drug transporters such as multidrug-resistance protein 1 (MDR1). PXR can be modulated by small molecules, including Federal Drug Administrat... |
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Thiazide-sensitive Na+ -Cl- cotransporter (NCC) gene inactivation results in increased duodenal Ca2+ absorption, enhanced osteoblast differentiation and elevated bone mineral density.
J. Bone Miner Res. 30(1) , 116-27, (2014) Inactivation of the thiazide-sensitive sodium chloride cotransporter (NCC) due to genetic mutations in Gitelman's syndrome (GS) or pharmacological inhibition with thiazide diuretics causes hypocalciuria and increased bone mineral density (BMD) with unclear ex... |
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Metolazone-induced cholestatic liver disease.
Dig. Liver Dis. 33(6) , 501, (2001)
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Self administration of metolzaone reduces readmissions with decompensated congestive cardiac failure.
Heart 82(3) , 397-8, (1999)
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Pathophysiology of functional mutations of the thiazide-sensitive Na-Cl cotransporter in Gitelman disease.
Am. J. Physiol. Renal Physiol. 287(2) , F195-203, (2004) Most of the missense mutations that have been described in the human SLC12A3 gene encoding the thiazide-sensitive Na(+)-Cl(-) cotransporter (TSC, NCC, or NCCT), as the cause of Gitelman disease, block TSC function by interfering with normal protein processing... |
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How much responsibility should heart failure nurses take?
Eur. J. Heart Fail. 7(3) , 351-61, (2005) This article examines the emerging role of the heart failure nurse and the responsibilities and educational and training requirements surrounding such a role. There may be variations in the role and its responsibilities in different health care settings. Howe... |