7-METHYLGUANOSINE
7-METHYLGUANOSINE structure
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Common Name | 7-METHYLGUANOSINE | ||
|---|---|---|---|---|
| CAS Number | 20244-86-4 | Molecular Weight | 298.27500 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C11H16N5O5+ | Melting Point | 165ºC | |
| MSDS | USA | Flash Point | N/A | |
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Artificial receptors for the extraction of nucleoside metabolite 7-methylguanosine from aqueous media made by molecular imprinting.
J. Chromatogr. A. 1365 , 12-8, (2014) A series of imprinted polymers targeting nucleoside metabolites, prepared using a template analogue approach, are presented. These were prepared following selection of the optimum functional monomer by solution association studies using (1)H NMR titrations wh... |
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Loss of a Conserved tRNA Anticodon Modification Perturbs Plant Immunity.
PLoS Genet. 11 , e1005586, (2015) tRNA is the most highly modified class of RNA species, and modifications are found in tRNAs from all organisms that have been examined. Despite their vastly different chemical structures and their presence in different tRNAs, occurring in different locations ... |
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Functional screen reveals SARS coronavirus nonstructural protein nsp14 as a novel cap N7 methyltransferase.
Proc. Natl. Acad. Sci. U. S. A. 106 , 3484-3489, (2009) The N7-methylguanosine (m7G) cap is the defining structural feature of eukaryotic mRNAs. Most eukaryotic viruses that replicate in the cytoplasm, including coronaviruses, have evolved strategies to cap their RNAs. In this report, we used a yeast genetic syste... |
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Structure of the yeast tRNA m7G methylation complex.
Structure 16 , 52-61, (2008) Loss of N7-methylguanosine (m7G) modification is involved in the recently discovered rapid tRNA degradation pathway. In yeast, this modification is catalyzed by the heterodimeric complex composed of a catalytic subunit Trm8 and a noncatalytic subunit Trm82. W... |
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mRNA cap recognition: dominant role of enhanced stacking interactions between methylated bases and protein aromatic side chains.
Proc. Natl. Acad. Sci. U. S. A. 96 , 7149-7154, (1999) We have determined, by high resolution x-ray analysis, 10 structures comprising the mRNA cap-specific methyltransferase VP39 or specific mutants thereof in the presence of methylated nucleobase analogs (N1-methyladenine, N3-methyladenine, N1-methylcytosine, N... |
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The "cap-binding slot" of an mRNA cap-binding protein: quantitative effects of aromatic side chain choice in the double-stacking sandwich with cap.
Biochemistry 41 , 7677-7687, (2002) The N7-methylguanine portion of the mRNA cap structure interacts with cap-binding proteins via an unusual double-stacking arrangement in which the positively charged cap is sandwiched between two parallel-oriented aromatic protein side chains. Three-dimension... |
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Wheat germ cytoplasmic ribosomes. Localization of 7-methylguanosine and 6-methyladenosine by electron microscopy of immune complexes.
J. Biol. Chem. 263 , 4939-4944, (1988) Nucleoside analysis of the RNA from the small subunit of wheat germ cytoplasmic ribosomes shows 1 mol each of N7-methylguanosine and N6-methyladenosine/mol of RNA. Antibodies directed against each methylated nucleoside were used to localize these residues wit... |
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Small-molecule inhibition of oncogenic eukaryotic protein translation in mesothelioma cells.
Invest. New Drugs 32(4) , 598-603, (2014) Deranged cap-mediated translation is implicated in the genesis, maintenance and progression of many human cancers including mesothelioma. In this study, disrupting the eIF4F complex by antagonizing the eIF4E-mRNA-cap interaction is assessed as a therapy for m... |