1,2-Dibromocyclopentene
1,2-Dibromocyclopentene structure
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Common Name | 1,2-Dibromocyclopentene | ||
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| CAS Number | 75415-78-0 | Molecular Weight | 225.909 | |
| Density | 2.1±0.1 g/cm3 | Boiling Point | 219.9±0.0 °C at 760 mmHg | |
| Molecular Formula | C5H6Br2 | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | 78.9±26.6 °C | |
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Selective mono- and 1,2-difunctionalisation of cyclopentene derivatives via Mg and Cu intermediates.
Chemistry 14 , 2499, (2008) A single Br/Mg exchange of 1,2-dibromocyclopentene with iPrMgCl LiCl provides the corresponding beta-bromocyclopentenylmagnesium reagent, which can then be reacted with various electrophiles (yields: 65-82 %). In the presence of a secondary alkylmagnesium hal... |
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The discovery of 6-[2-(5-chloro-2-{[(2,4-difluorophenyl)methyl]oxy}phenyl)-1-cyclopenten-1-yl]-2-pyridinecarboxylic acid, GW848687X, a potent and selective prostaglandin EP1 receptor antagonist for the treatment of inflammatory pain.
Bioorg. Med. Chem. Lett. 17(2) , 385-9, (2007) The discovery of a series of selective EP1 receptor antagonists based on a 1,2-diarylcyclopentene template is described. After defining the structural requirements for EP1 potency and selectivity, heterocyclic rings were incorporated to reduce logD and improv... |
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