SG 209
SG 209 structure
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Common Name | SG 209 | ||
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| CAS Number | 83440-03-3 | Molecular Weight | 208.21400 | |
| Density | 1.182g/cm3 | Boiling Point | 430.7ºC at 760 mmHg | |
| Molecular Formula | C10H12N2O3 | Melting Point | N/A | |
| MSDS | USA | Flash Point | 214.3ºC | |
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ATP-sensitive potassium channel activation induces angiogenesis in vitro and in vivo.
J. Pharmacol. Exp. Ther. 354 , 79-87, (2015) Intense research is conducted to identify new molecular mechanisms of angiogenesis. Previous studies have shown that the angiogenic effects of hydrogen sulfide (H2S) depend on the activation of ATP-sensitive potassium channels (KATP) and that C-type natriuret... |
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Nicorandil inhibits degranulation and TNF-alpha release from RBL-2H3 cells.
Inflamm. Res. 51 , 176-181, (2002) Nicorandil is a potassium channel opener and nitric oxide (NO) donor, and the hypothesis was tested that these modes of action may inhibit cellular degranulation and release of tumour necrosis factor-alpha (TNF-alpha).TNF-alpha and beta-hexosaminidase secreti... |
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A further study of the vasodilator and negative inotropic mechanisms of action of nicorandil and its congeners in the canine heart.
Cardiovasc. Drugs Ther. 8 , 227-234, (1994) The vasodilator and negative inotropic mechanisms of action of nicorandil and its congeners (SG-209, SG-103, and SG-86) were investigated in isolated canine papillary muscle preparations cross-circulated through the anterior septal artery with support dogs. S... |
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2-Nicotinamidoethyl acetate (SG-209) is a potassium channel opener: structure activity relationship among nicorandil derivatives.
Naunyn Schmiedebergs Arch. Pharmacol. 344 , 235-239, (1991) The mechanism of the vasodilating action of 2-nicotinamidoethyl acetate (SG-209), a derivative of nicorandil, was examined in the isolated rabbit aorta. Comparison was made using 2-nicotinamidoethyl alcohol (SG-86) and 2-nicotinamidoethyl nitrate (nicorandil;... |
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Effects of nicorandil and its congeners on musculature and vasculature of the dog trachea in situ.
Arch. Int. Pharmacodyn. Ther. 258(2) , 260-6, (1982) In anesthetized dogs, the tracheal vascular bed in situ was perfused with arterial blood through the cannulated cranial thyroid arteries. The effects of nicorandil, a coronary vasodilator, and its congeners (SG-212, GS-209 and SG-103; in which the nitroxy gro... |
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Nicorandil inhibits the release of TNFalpha from a lymphocyte cell line and peripheral blood lymphocytes.
Int. Immunopharmacol. 3(12) , 1581-8, (2003) Modulation of cytokine release may be of interest in modulating inflammatory diseases. This study determined whether nicorandil, a potassium channel opener, and nitric oxide (NO) donor could inhibit the release of tumour necrosis factor alpha (TNFalpha) from ... |
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Effects of nicorandil on cytosolic calcium concentrations and on tension development in the rabbit femoral artery.
J. Pharmacol. Exp. Ther. 268(2) , 762-71, (1994) By using front-surface fluorometry and fura-2-loaded strips of the rabbit femoral artery, the effects of 2-nicotinamidoethyl nitrate (nicorandil) on cytosolic Ca++ concentration ([Ca++]i) and on tension development were measured simultaneously, and findings w... |
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Effects of N-(2-hydroxyethyl)nicotinamide nitrate (nicorandil; SG-75) and its derivatives on pancreatic exocrine secretion in the dog.
Pancreas 5(1) , 75-81, (1990) Nicorandil, a compound containing a nitrate moiety, can act as a K+ channel opener. Previously we reported stimulatory effects of an intraarterial injection of nicorandil on pancreatic exocrine secretion in the isolated, blood-perfused pancreas under a consta... |
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The effect of a nicorandil congener on isolated human myometrium.
Eur. J. Obstet. Gynecol. Reprod. Biol. 126(2) , 176-9, (2006) To determine the effect of a nicorandil congener, SG-209 on the myometrium.Isolated strips of myometrium, from nine women who underwent hysterectomy, were made to contract with 55 mM KCl before and after incubation with three concentrations of SG-209 (1.5, 3.... |