Purmorphamine
Purmorphamine structure
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Common Name | Purmorphamine | ||
|---|---|---|---|---|
| CAS Number | 483367-10-8 | Molecular Weight | 520.625 | |
| Density | 1.4±0.1 g/cm3 | Boiling Point | 790.3±70.0 °C at 760 mmHg | |
| Molecular Formula | C31H32N6O2 | Melting Point | 210-212ºC | |
| MSDS | Chinese USA | Flash Point | 431.8±35.7 °C | |
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Co-ordinated brain and craniofacial development depend upon Patched1/XIAP regulation of cell survival.
Hum. Mol. Genet. 24(3) , 698-713, (2015) Congenital brain and craniofacial defects often occur together as a consequence of their developmental dependency on common progenitor tissue interactions and signaling pathways during embryogenesis. A classic example of this is perturbation of midline embryo... |
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Susceptibility of human embryonic stem cell-derived neural cells to Japanese encephalitis virus infection.
PLoS ONE 9(12) , e114990, (2014) Pluripotent human embryonic stem cells (hESCs) can be efficiently directed to become immature neuroepithelial precursor cells (NPCs) and functional mature neural cells, including neurotransmitter-secreting neurons and glial cells. Investigating the susceptibi... |
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Generation of neuropeptidergic hypothalamic neurons from human pluripotent stem cells.
Development 142(4) , 633-43, (2015) Hypothalamic neurons orchestrate many essential physiological and behavioral processes via secreted neuropeptides, and are relevant to human diseases such as obesity, narcolepsy and infertility. We report the differentiation of human pluripotent stem cells in... |
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Cdo suppresses canonical Wnt signalling via interaction with Lrp6 thereby promoting neuronal differentiation.
Nat. Commun. 5 , 5455, (2014) Canonical Wnt signalling regulates expansion of neural progenitors and functions as a dorsalizing signal in the developing forebrain. In contrast, the multifunctional co-receptor Cdo promotes neuronal differentiation and is important for the function of the v... |
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Molecular mechanism for USP7-mediated DNMT1 stabilization by acetylation.
Nat. Commun. 6 , 7023, (2015) DNMT1 is an important epigenetic regulator that plays a key role in the maintenance of DNA methylation. Here we determined the crystal structure of DNMT1 in complex with USP7 at 2.9 Å resolution. The interaction between the two proteins is primarily mediated ... |
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Sensory neurons do not induce motor neuron loss in a human stem cell model of spinal muscular atrophy.
PLoS ONE 9(7) , e103112, (2014) Spinal muscular atrophy (SMA) is an autosomal recessive disorder leading to paralysis and early death due to reduced SMN protein. It is unclear why there is such a profound motor neuron loss, but recent evidence from fly and mouse studies indicate that cells ... |
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Generation of eye field/optic vesicle-like structures from human embryonic stem cells under two-dimensional and chemically defined conditions.
In Vitro Cell. Dev. Biol. Anim. 51(3) , 310-8, (2015) Despite the enormous progress in studying retinal cell differentiation from human embryonic stem cells (hESCs), none of the reported protocols have produced a cost-effective eye field cells with the capability to further differentiate into retinal derivatives... |
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X-linked severe combined immunodeficiency (X-SCID) rats for xeno-transplantation and behavioral evaluation.
J. Neurosci. Methods 243 , 68-77, (2015) To evaluate the in vivo function of human dopaminergic (DA) neurons, Parkinson's disease (PD) model rats made by the hemi-lateral injection of 6-hydroxydopamine (6-OHDA) are widely used as host animals. In the case of such xeno-transplantation, however, immun... |
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Non-genetic direct reprogramming and biomimetic platforms in a preliminary study for adipose-derived stem cells into corneal endothelia-like cells.
PLoS ONE 9(10) , e109856, (2014) Cell fate and function can be regulated and reprogrammed by intrinsic genetic program, extrinsic factors and niche microenvironment. Direct reprogramming has shown many advantages in the field of cellular reprogramming. Here we tried the possibility to genera... |
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Intermediate filament protein accumulation in motor neurons derived from giant axonal neuropathy iPSCs rescued by restoration of gigaxonin.
Hum. Mol. Genet. 24(5) , 1420-31, (2015) Giant axonal neuropathy (GAN) is a progressive neurodegenerative disease caused by autosomal recessive mutations in the GAN gene resulting in a loss of a ubiquitously expressed protein, gigaxonin. Gene replacement therapy is a promising strategy for treatment... |