7-Diethylamino-3-(4-maleimidophenyl)-4-methylcoumarin
7-Diethylamino-3-(4-maleimidophenyl)-4-methylcoumarin structure
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Common Name | 7-Diethylamino-3-(4-maleimidophenyl)-4-methylcoumarin | ||
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| CAS Number | 76877-33-3 | Molecular Weight | 402.44200 | |
| Density | 1.302 g/cm3 | Boiling Point | 618.7ºC at 760 mmHg | |
| Molecular Formula | C24H22N2O4 | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | 328ºC | |
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Co-expression of human agouti-related protein enhances expression and stability of human melanocortin-4 receptor.
Biochem. Biophys. Res. Commun. 456(1) , 116-21, (2014) G protein-coupled receptors (GPCRs) represent the largest family of transmembrane signaling proteins, and they are considered major targets of approximately half of all therapeutic agents. Human melanocortin-4 receptor (hMC4R) plays an important role in the c... |
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Identification of 2-[2-(4-tert-butylphenyl)ethyl]-N-(4-fluorophenyl)-1,2,3,4-tetrahydroisoquinoline-6-sulfonamide (29) as an orally available MGAT2 inhibitor.
Bioorg. Med. Chem. 23 , 5922-31, (2015) MGAT2 (monoacylglycerol acyltransferase 2) is expected to be an attractive target for the drug treatment of obesity, diabetes, and other disease. We describe our exploration and structure-activity relationship (SAR) study of 2,3-dihydro-1H-isoindole-5-sulfona... |
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N-terminal region of the catalytic domain of human N-myristoyltransferase 1 acts as an inhibitory module.
PLoS ONE 10 , e0127661, (2015) N-myristoyltransferase (NMT) plays critical roles in the modulation of various signaling molecules, however, the regulation of this enzyme in diverse cellular states remains poorly understood. We provide experimental evidence to show for the first time that f... |
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Individual differences in acute pain-induced endogenous analgesia predict time to resolution of postoperative pain in the rat.
Anesthesiology 122(4) , 895-907, (2015) Chronic postsurgical pain, a significant public health problem, occurs in 10 to 50% of patients undergoing major surgery. Acute pain induces endogenous analgesia termed conditioned pain modulation (CPM), and the strength of CPM preoperatively predicts the lik... |
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Efflux pump gene expression in multidrug-resistant Mycobacterium tuberculosis clinical isolates.
PLoS ONE 10(2) , e0119013, (2015) Isoniazid (INH) and rifampicin (RIF) are the two most effective drugs in tuberculosis therapy. Understanding the molecular mechanisms of resistance to these two drugs is essential to quickly diagnose multidrug-resistant (MDR) tuberculosis and extensive drug-r... |
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Cancer associated fibroblasts transfer lipids and proteins to cancer cells through cargo vesicles supporting tumor growth.
Biochim. Biophys. Acta 1853 , 3211-23, (2015) Fibroblasts are the most abundant cells in connective tissue and, with fibrillar extracellular matrix, form the structural scaffolding of organs. In solid tumors, interaction with cancer cells induces fibroblasts transdifferentiation into an activated form, w... |
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Phenotypic and genotypic diversity in a multinational sample of drug-resistant Mycobacterium tuberculosis isolates.
Int. J. Tuberc. Lung Dis. 19(4) , 420-7, (2015) To develop and evaluate rapid, molecular-based drug susceptibility testing (DST) for extensively drug-resistant tuberculosis (XDR-TB), we assembled a phenotypically and genotypically diverse collection of Mycobacterium tuberculosis isolates from patients eval... |
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Distinct brain mechanisms support spatial vs temporal filtering of nociceptive information.
Pain 155(12) , 2491-501, (2014) The role of endogenous analgesic mechanisms has largely been viewed in the context of gain modulation during nociceptive processing. However, these analgesic mechanisms may play critical roles in the extraction and subsequent utilization of information relate... |
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Cysteine residue is not essential for CPM protein thermal-stability assay.
Anal. Bioanal. Chem 407(13) , 3683-91, (2015) A popular thermal-stability assay developed especially for the study of membrane proteins uses a thiol-specific probe, 7-diethylamino-3-(4-maleimidophenyl)-4-methylcoumarin (CPM). The fluorescence emission of CPM surges when it forms a covalent bond with the ... |
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A fluorescence-based assay for N-myristoyltransferase activity.
Anal. Biochem. 421(1) , 342-4, (2012) N-myristoylation is the irreversible attachment of a C(14) fatty acid, myristic acid, to the N-terminal glycine of a protein via formation of an amide bond. This modification is catalyzed by myristoyl-coenzyme A (CoA):protein N-myristoyltransferase (NMT), an ... |