L-Homocysteine thiolactone hydrochloride
L-Homocysteine thiolactone hydrochloride structure
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Common Name | L-Homocysteine thiolactone hydrochloride | ||
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| CAS Number | 31828-68-9 | Molecular Weight | 153.630 | |
| Density | N/A | Boiling Point | 253.8ºC at 760mmHg | |
| Molecular Formula | C4H8ClNOS | Melting Point | 185-191ºC | |
| MSDS | USA | Flash Point | 107.3ºC | |
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Quality control in tRNA charging -- editing of homocysteine.
Acta Biochim. Pol. 58 , 149-163, (2011) All living organisms conduct protein synthesis with a high degree of accuracy maintained in the transmission and flow of information from a gene to protein product. One crucial 'quality control' point in maintaining a high level of accuracy is the selectivity... |
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Homocysteine and its thiolactone-mediated modification of fibrinogen affect blood platelet adhesion.
Platelets 23(5) , 409-12, (2011) Homocysteine (Hcys) and homocysteine thiolactone (HTL) concentrations in organism are correlated with a number of serious pathologies. In the literature, there are few papers describing studies on the effects of homocysteine on proteins that participate in bl... |
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Effect of homocysteine thiolactone on structure and aggregation propensity of bovine pancreatic insulin.
Protein J. 30 , 299-307, (2011) Homocysteine thiolactone (HCTL) is a cyclic thioester of homocysteine, showing high reactivity toward lysine residues of proteins. In the present study the structural properties and aggregation propensity of bovine pancreatic insulin were studied in the prese... |
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Anticonvulsive effect of folic acid in homocysteine thiolactone-induced seizures.
Cell. Mol. Neurobiol. 31 , 1221-1228, (2011) Numerous studies have linked folate deficiency and resultant elevated plasma homocysteine levels with an increased risk of neurodegenerative diseases and seizures. The aim of the present study was to examine the effect of acute folic acid administration on be... |
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The effect of N-methyl-D-aspartate receptor antagonists on D,L-homocysteine thiolactone induced seizures in adult rats.
Acta Physiol. Hung. 98 , 17-26, (2011) The aim of our study was to investigate the effects of ifenprodil and MK-801 on D,L-homocysteine thiolactone induced seizures in adult rats.Male Wistar rats were divided into following groups: 1. Saline-treated (C, n=10); 2. D,L-homocysteine thiolactone 8 mmo... |
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Intravitreal homocysteine-thiolactone injection leads to the degeneration of multiple retinal cells, including photoreceptors.
Mol. Vis. 17 , 1946-1956, (2011) Hyperhomocysteinemia is known to cause degeneration of retinal ganglion cells, but its influence on photoreceptors remains largely unknown. In particular, the role of homocysteine-thiolactone (Hcy-T)--the physiologic metabolite of homocysteine that has been p... |
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Homocysteinylated fibrinogen forms disulfide-linked complexes with albumin.
Thromb. Res. 127 , 576-581, (2011) We have shown that homocysteinemic rabbits have altered fibrinogen that forms fibrin clots with increased resistance to fibrinolysis. Homocysteine thiolactone is a metabolite of homocysteine (Hcys) that can react with amines and introduce a new sulfhydryl gro... |