α-tocotrienol
α-tocotrienol structure
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Common Name | α-tocotrienol | ||
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| CAS Number | 1721-51-3 | Molecular Weight | 424.65800 | |
| Density | 0.96g/cm3 | Boiling Point | 541.7ºC at 760mmHg | |
| Molecular Formula | C29H44O2 | Melting Point | N/A | |
| MSDS | Chinese USA | Flash Point | 222.3ºC | |
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Tocotrienols promote apoptosis in human breast cancer cells by inducing poly(ADP-ribose) polymerase cleavage and inhibiting nuclear factor kappa-B activity.
Cell Prolif. 46(2) , 203-13, (2013) Tocotrienols and tocopherols are members of the vitamin E family, with similar structures; however, only tocotrienols have been reported to achieve potent anti-cancer effects. The study described here has evaluated anti-cancer activity of vitamin E to elucida... |
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Tissue distribution of vitamin E metabolites in rats after oral administration of tocopherol or tocotrienol.
J. Nutr. Sci. Vitaminol. 57(5) , 326-32, (2011) We previously found that 2,7,8-trimethyl-2(2'-carboxyethyl)-6-hydroxychroman (_CEHC), a metabolite of the vitamin E isoforms _-tocopherol or _-tocotrienol, accumulated in the rat small intestine. The aim of this study was to evaluate tissue distribution of vi... |
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δ- and γ-tocotrienols induce classical ultrastructural apoptotic changes in human T lymphoblastic leukemic cells.
Microsc. Microanal. 18(3) , 462-9, (2012) Tocotrienols are isomers of the vitamin E family, which have been reported to exert cytotoxic effects in various cancer cells. Although there have been some reports on the effects of tocotrienols in leukemic cells, ultrastructural evidence of tocotrienol-indu... |
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Tocotrienols prevent hydrogen peroxide-induced axon and dendrite degeneration in cerebellar granule cells.
Free Radic. Res. 46(2) , 184-93, (2012) It is well known that reactive oxygen species (ROS) attack several living tissues and increase the risk of development and progression of serious diseases. In neuronal level, ROS induce cell death in concentration-dependent fashion. However, little is known a... |
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Classification and prediction of clinical diagnosis of Alzheimer's disease based on MRI and plasma measures of α-/γ-tocotrienols and γ-tocopherol.
J. Intern. Med. 273(6) , 602-21, (2013) The aim of this study was to evaluate the accuracy of combined structural magnetic resonance imaging (MRI) measures and plasma levels of vitamin E forms, including all eight natural vitamin E congeners (four tocopherols and four tocotrienols) and markers of v... |
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A key regulator of cholesterol homoeostasis, SREBP-2, can be targeted in prostate cancer cells with natural products.
Biochem. J. 446(2) , 191-201, (2012) There is growing evidence showing that prostate cancer cells have perturbed cholesterol homoeostasis, accumulating cholesterol to promote cell growth. Consequently, cholesterol-lowering drugs such as statins are being evaluated in prostate cancer treatment. F... |
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α-Tocotrienol quinone modulates oxidative stress response and the biochemistry of aging
Bioorg. Med. Chem. Lett. 21 , 3693-3698, (2011) We report that α-tocotrienol quinone (ATQ3) is a metabolite of α-tocotrienol, and that ATQ3 is a potent cellular protectant against oxidative stress and aging. ATQ3 is orally bioavailable, crosses the blood-brain barrier, and has demonstrated clinical respons... |
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Tocotrienol enriched palm oil prevents atherosclerosis through modulating the activities of peroxisome proliferators-activated receptors.
Atherosclerosis 211 , 278-82, (2010) Palm oil is enriched in vitamin E in the form of alpha-, gamma-, and delta-tocotrienols. Dietary tocotrienol supplements have been shown to prevent atherosclerosis development in patients and preclinical animal models. However, the mechanistic basis for this ... |
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Triton WR1339, an inhibitor of lipoprotein lipase, decreases vitamin E concentration in some tissues of rats by inhibiting its transport to liver.
J. Nutr. 137(2) , 345-50, (2007) The aim of this experiment was to clarify the contribution of the alpha-tocopherol transfer activity of lipoprotein lipase (LPL) to vitamin E transport to tissues in vivo. We studied the effect of Triton WR1339, which prevents the catabolism of triacylglycero... |
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Induction of DNA damage and caspase-independent programmed cell death by vitamin E.
Nutr. Cancer 64(1) , 136-52, (2012) Vitamin E comprises 8 functionally unique isoforms and may be a suitable candidate for the adjuvant treatment of prostate cancer. In this study, we examined the ability of 2 vitamin E isoforms [α-tocotrienol (γ-TT) and δ-tocotrienol (δ-TT)] and 4 synthetic de... |