OXAMIC ACID

OXAMIC ACID Structure
OXAMIC ACID structure
Common Name OXAMIC ACID
CAS Number 471-47-6 Molecular Weight 89.05010
Density 1.563g/cm3 Boiling Point 306.3ºC at 760mmHg
Molecular Formula C2H3NO3 Melting Point 207-210 °C (dec.)(lit.)
MSDS USA Flash Point N/A

Ketogenic response to cotreatment with bezafibrate and medium chain triacylglycerols in healthy humans.

Nutrition 31 , 1255-9, (2015)

The aim of this study was to compare the ketogenic effect of the peroxisome proliferator-activated receptor-α stimulator, bezafibrate (BEZA), alone or in combination with medium-chain triacylglycerols (MCTs) in healthy adults.Eighteen healthy adults completed...

The dissociation chemistry of ionized methyl carbamate and its isomers revisited: theory and experiment in concert.

Eur. J. Mass Spectrom. (Chichester, Eng.) 18(2) , 149-59, (2012)

Early combined computational and experimental studies by J.K. Terlouw c.s. in Refs. 1-3 propose that low-energy methyl carbamate ions, NH(2)COOCH(3)(•+) (MC-1), rearrange into distonic ions NH(2)C(OH)OCH(2)(•+) and hydrogen-bridged radical cations [NH(2)C=O--...

Effects of three modifiers of glycolysis on ATP, lactate, hypoxia, and growth in human tumor cell lines in vivo.

Strahlenther. Onkol. 188(5) , 431-7, (2012)

High pretreatment tumor lactate content is associated with poor outcome after fractionated irradiation in human squamous cell carcinoma (hSCC) xenografts. Therefore, decreasing lactate content might be a promising approach for increasing tumor radiosensitivit...

Lactate-induced release of GABA in the ventromedial hypothalamus contributes to counterregulatory failure in recurrent hypoglycemia and diabetes.

Diabetes 62(12) , 4239-46, (2013)

Suppression of GABAergic neurotransmission in the ventromedial hypothalamus (VMH) is crucial for full activation of counterregulatory responses to hypoglycemia, and increased γ-aminobutyric acid (GABA) output contributes to counterregulatory failure in recurr...

Does S-metolachlor affect the performance of Pseudomonas sp. strain ADP as bioaugmentation bacterium for atrazine-contaminated soils?

PLoS ONE 7(5) , e37140, (2012)

Atrazine (ATZ) and S-metolachlor (S-MET) are two herbicides widely used, often as mixtures. The present work examined whether the presence of S-MET affects the ATZ-biodegradation activity of the bioaugmentation bacterium Pseudomonas sp. strain ADP in a crop s...

Meningeal blood flow is controlled by H2 S-NO crosstalk activating a HNO-TRPA1-CGRP signalling pathway.

Br. J. Pharmacol. 173 , 431-45, (2016)

Meningeal blood flow is controlled by CGRP released from trigeminal afferents and NO mainly produced in arterial endothelium. The vasodilator effect of NO may be due to the NO-derived compound, nitroxyl (HNO), generated through reaction with endogenous H2 S. ...

Synthesis and antiviral activity of novel HCV NS3 protease inhibitors with P4 capping groups

Bioorg. Med. Chem. Lett. 22(24) , 7351-6, (2012)

We have synthesized and evaluated a series of novel HCV NS3 protease inhibitors with various P4 capping groups, which include urea, carbamate, methoxy-carboxamide, cyclic carbamate and amide, pyruvic amide, oxamate, oxalamide and cyanoguanidine. Most of these...

Oxamate is an alternative substrate for pyruvate carboxylase from Rhizobium etli.

Biochemistry 52(17) , 2888-94, (2013)

Oxamate, an isosteric and isoelectronic inhibitory analogue of pyruvate, enhances the rate of enzymatic decarboxylation of oxaloacetate in the carboxyl transferase domain of pyruvate carboxylase (PC). It is unclear, though, how oxamate exerts a stimulatory ef...

Synthesis of N-glucopyranosidic derivatives as potential inhibitors that bind at the catalytic site of glycogen phosphorylase.

Mini Rev. Med. Chem. 10(12) , 1127-38, (2010)

Glycogen phosphorylase (GP) is a promising molecular target for the treatment of Type 2 diabetes. The design of potential inhibitors for the catalytic site of the enzyme is based on the high affinity for β-D-glucopyranose and the presence of a β-cavity that e...

Physicobiological properties and biocompatibility of biodegradable poly(oxalate-co-oxamide).

J. Biomed. Mater. Res. A 98(4) , 517-26, (2011)

The development of biodegradable and biocompatible materials is the basis for tissue engineering and drug delivery. The aims of this study are to develop the poly(oxalate-co-oxamide) (POXAM) and evaluate its physicochemical properties and biocompatibility as ...