Methyllycaconitine citrate
Methyllycaconitine citrate structure
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Common Name | Methyllycaconitine citrate | ||
|---|---|---|---|---|
| CAS Number | 112825-05-5 | Molecular Weight | 874.92400 | |
| Density | N/A | Boiling Point | N/A | |
| Molecular Formula | C43H58N2O17 | Melting Point | N/A | |
| MSDS | USA | Flash Point | N/A | |
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A potentially novel nicotinic receptor in Aplysia neuroendocrine cells.
J. Neurophysiol. 112(2) , 446-62, (2014) Nicotinic receptors form a diverse group of ligand-gated ionotropic receptors with roles in both synaptic transmission and the control of excitability. In the bag cell neurons of Aplysia, acetylcholine activates an ionotropic receptor, which passes inward cur... |
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Changes in Nicotinic Neurotransmission during Enteric Nervous System Development.
J. Neurosci. 35 , 7106-15, (2015) Acetylcholine-activating pentameric nicotinic receptors (nAChRs) are an essential mode of neurotransmission in the enteric nervous system (ENS). In this study, we examined the functional development of specific nAChR subtypes in myenteric neurons using Wnt1-C... |
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TRIM29 regulates the assembly of DNA repair proteins into damaged chromatin.
Nat. Commun. 6 , 7299, (2015) Although DNA double-strand break (DSB) repair is mediated by numerous proteins accumulated at DSB sites, how DNA repair proteins are assembled into damaged chromatin has not been fully elucidated. Here we show that a member of the tripartite motif protein fam... |
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Acetylcholine excites neocortical pyramidal neurons via nicotinic receptors.
J. Neurophysiol. 113 , 2195-209, (2015) The neuromodulator acetylcholine (ACh) shapes neocortical function during sensory perception, motor control, arousal, attention, learning, and memory. Here we investigate the mechanisms by which ACh affects neocortical pyramidal neurons in adult mice. Stimula... |
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Pro-cognitive activity in rats of 3-furan-2-yl-N-p-tolyl-acrylamide, a positive allosteric modulator of the α7 nicotinic acetylcholine receptor.
Br. J. Pharmacol. 172 , 5123-35, (2015) α7 nicotinic acetylcholine receptors (α7 nAChRs) may represent useful targets for cognitive improvement. The aim of this study is to compare the pro-cognitive activity of selective α7-nAChR ligands, including the partial agonists, DMXBA and A-582941, as well ... |
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Modulation of AMPA receptor mediated current by nicotinic acetylcholine receptor in layer I neurons of rat prefrontal cortex.
Sci. Rep. 5 , 14099, (2015) Layer I neurons in the prefrontal cortex (PFC) exhibit extensive synaptic connections with deep layer neurons, implying their important role in the neural circuit. Study demonstrates that activation of nicotinic acetylcholine receptors (nAChRs) increases exci... |
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High-Affinity Nicotinic Receptors Modulate Spontaneous Cortical Up States In Vitro.
J. Neurosci. 35 , 11196-208, (2015) Nicotinic acetylcholine receptors (nAChRs) play an important role in the modulation of many cognitive functions but their role in integrated network activity remains unclear. This is at least partly because of the complexity of the cholinergic circuitry and t... |
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Dopaminergic and cholinergic modulation of striatal tyrosine hydroxylase interneurons.
Neuropharmacology 95 , 468-76, (2015) The recent electrophysiological characterization of TH-expressing GABAergic interneurons (THINs) in the neostriatum revealed an unexpected degree of diversity of interneurons in this brain area (Ibáñez-Sandoval et al., 2010, Unal et al., 2011, 2015). Despite ... |
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(R,S)-Ketamine metabolites (R,S)-norketamine and (2S,6S)-hydroxynorketamine increase the mammalian target of rapamycin function.
Anesthesiology 121(1) , 149-59, (2014) Subanesthetic doses of (R,S)-ketamine are used in the treatment of neuropathic pain and depression. In the rat, the antidepressant effects of (R,S)-ketamine are associated with increased activity and function of mammalian target of rapamycin (mTOR); however, ... |
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3,4-Methylenedioxy-methamphetamine induces in vivo regional up-regulation of central nicotinic receptors in rats and potentiates the regulatory effects of nicotine on these receptors.
Neurotoxicology 35 , 41-9, (2013) Nicotine (NIC), the main psychostimulant compound of smoked tobacco, exerts its effects through activation of central nicotinic acetylcholine receptors (nAChR), which become up-regulated after chronic administration. Recent work has demonstrated that the recr... |