β-cyclodextrin
β-cyclodextrin structure
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Common Name | β-cyclodextrin | ||
|---|---|---|---|---|
| CAS Number | 7585-39-9 | Molecular Weight | 1134.984 | |
| Density | 1.6±0.1 g/cm3 | Boiling Point | 1541.2±60.0 °C at 760 mmHg | |
| Molecular Formula | C42H70O35 | Melting Point | >260ºC (dec.)(lit.) | |
| MSDS | Chinese USA | Flash Point | 885.9±32.9 °C | |
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β-cyclodextrin and curcumin, a potent cocktail for disaggregating and/or inhibiting amyloids: a case study with α-synuclein.
Biochemistry 53(25) , 4081-3, (2014) Aggregation of α-synuclein has been implicated in Parkinson's disease (PD). While many compounds are known to inhibit α-synuclein aggregation, dissolution of aggregates into their constituent monomers cannot be readily achieved. In this study, using a range o... |
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CDDP supramolecular micelles fabricated from adamantine terminated mPEG and β-cyclodextrin based seven-armed poly (L-glutamic acid)/CDDP complexes.
Colloids Surf. B Biointerfaces 105 , 31-6, (2013) This research is aimed to develop a nano-sized supramolecular micelle delivery system of cis-dichlorodiammine platinum (II) (CDDP) in order to achieve the passive tumor targeting. Firstly, star-shaped poly (γ-benzyl-L-glutamate) was synthesized by the ring-op... |
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Characterization of the hydrochlorothiazide: β-cyclodextrin inclusion complex. Experimental and theoretical methods.
J. Phys. Chem. B 117(1) , 206-17, (2013) Hydrochlorothiazide (HCT) is one of the most commonly prescribed antihypertensive drugs. In an attempt to gain an insight into the physicochemical and molecular aspects controlling the complex architecture of native β-cyclodextrin (β-CD) with HCT, we performe... |
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Purification, crystallization and preliminary crystallographic analysis of the marine α-amylase AmyP.
Acta Crystallogr. Sect. F Struct. Biol. Cryst. Commun. 69(Pt 3) , 263-6, (2013) AmyP is a raw-starch-degrading α-amylase newly identified from a marine metagenome library. It shares low sequence similarity with characterized glycoside hydrolases and was classified into a new subfamily of GH13. In particular, it showed preferential degrad... |
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Compression-coated tablets of glipizide using hydroxypropylcellulose for zero-order release: in vitro and in vivo evaluation.
Int. J. Pharm. 446(1-2) , 211-8, (2013) Compression coating, which presents some advantages like short manufacturing process and non-solvent residue over liquid coating, has been introduced to the oral administration systems for decades. The purpose of this study was to design a zero-order release ... |
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Influence of beta-cyclodextrin and chitosan in the formulation of a colon-specific drug delivery system.
Drug Res. (Stuttg.) 63(12) , 657-62, (2013) The increase in diseases of the colon underscores the need to develop cost-effective site-directed therapies. We formulated a polysaccharide-based matrix system that could release ibuprofen under conditions simulating those in the colon by employing a wet gra... |
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Hydrophilic versus hydrophobic porogens for engineering of poly(lactide-co-glycolide) microparticles containing risedronate sodium.
Pharm. Dev. Technol. 18(5) , 1078-88, (2013) The aim of this study was to investigate the effect of two mechanistically different porogens, namely: the hydrophilic hydroxy-propyl-β-cyclodextrin and the hydrophobic porogens (mineral oil and corn oil) in producing open/closed pored engineered polylactide-... |
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High-throughput phase-distribution method to determine drug-cyclodextrin binding constants.
J. Pharm. Sci. 98(1) , 229-38, (2009) A high-throughput method has been developed to measure drug-cyclodextrin binding constants. It measures the distribution ratio of a drug between a polymer film [polyvinyl chloride (PVC) with 67% (w/w) dioctyl sebacate (DOS)] and a cyclodextrin-containing buff... |
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Versatile fluorescence resonance energy transfer-based mesoporous silica nanoparticles for real-time monitoring of drug release.
ACS Nano 7(3) , 2741-50, (2013) We describe the development of a versatile fluorescence resonance energy transfer (FRET)-based real-time monitoring system, consisting of (a) coumarin-labeled-cysteine tethered mesoporous silica nanoparticles (MSNs) as the drug carrier, (b) a fluorescein isot... |
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Preparation of agar nanospheres: comparison of response surface and artificial neural network modeling by a genetic algorithm approach.
Carbohydr. Polym. 122 , 314-20, (2015) Multivariate nature of drug loaded nanospheres manufacturing in term of multiplicity of involved factors makes it a time consuming and expensive process. In this study genetic algorithm (GA) and artificial neural network (ANN), two tools inspired by natural p... |