Captopril disulfide
Captopril disulfide structure
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Common Name | Captopril disulfide | ||
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| CAS Number | 64806-05-9 | Molecular Weight | 432.55500 | |
| Density | 1.383g/cm3 | Boiling Point | 714.796ºC at 760 mmHg | |
| Molecular Formula | C18H28N2O6S2 | Melting Point | 224-226ºC | |
| MSDS | Chinese USA | Flash Point | 386.095ºC | |
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Captopril disulfide conjugates may act as prodrugs: disposition of the disulfide dimer of captopril in the rat.
Biochem. Pharmacol. 33(22) , 3567-71, (1984) The absorption and metabolism of the disulfide dimer conjugate of captopril has been studied in the rat following both oral and intravenous dosing and compared with that of the active monomer, captopril. Metabolism of the dimer to captopril has been shown aft... |
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The pharmacokinetics of captopril and captopril disulfide conjugates in uraemic patients on maintenance dialysis: comparison with patients with normal renal function.
Eur. J. Clin. Pharmacol. 32(3) , 267-71, (1987) We have measured the plasma concentrations of captopril and total disulfide conjugates of captopril after a 50 mg oral dose in 6 uraemic patients on maintenance dialysis and in 8 hypertensive subjects with normal renal function. The mean peak plasma concentra... |
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[Determination of captopril plus its disulfide metabolites in human plasma].
Yao Xue Xue Bao 33(8) , 605-9, (1998) A new and sensitive HPLC method has been developed for the determination of captopril plus its disulfide metabolites (total captopril) in human plasma. Captopril disulfides and the drug covalently bound to protein were reduced with sodium borohydride to capto... |
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Bradykinin-potentiating activity of captopril disulphide dimer (SQ 14,551).
Eur. J. Pharmacol. 153(1) , 11-7, (1988) The ability of captopril and one of its metabolites, the disulphide dimer have been studied for their ability to affect angiotensin I and bradykinin responses. Captopril disulphide dimer (i.v.) potentiated the vasodilatory effects of bradykinin in urethane-an... |
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Captopril and its dimer captopril disulfide: Photodegradation, aerobic biodegradation and identification of transformation products by HPLC–UV and LC–ion trap-MSn
Chemosphere 88(10) , 1170-7, (2012) Highlights ► Captopril (CP) is widely used in Egypt for hypertension. ► Nile River suffers from pollution due to direct and indirect sanitation. ► CP underwent dimerization to Captopril Disulfide (CPDS). ► CP and CPDS underwent abiotic, photo and transformati... |
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Spectrofluorometric determination of captopril plus captopril disulfide metabolites in plasma.
J. Pharm. Sci. 73(10) , 1427-30, (1984) Captopril disulfides and the drug covalently bound to proteins were reduced with tri-n-butylphosphine. After sample purification on an XAD-2 column, captopril was treated with 1-(7-dimethylamino)-4-methyl-2-oxo-2H -1-benzopyran-3-yl)-1H-pyrrole-2,5-dione to f... |
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Quantitative determination of captopril in blood and captopril and its disulfide metabolites in plasma by gas chromatography.
J. Pharm. Sci. 73(3) , 340-4, (1984) A sensitive, quantitative gas chromatographic-electron capture (GC-EC) method for the determination of captopril in blood and captopril and its disulfide metabolites (collectively) in plasma was developed. After addition of an internal standard and N-ethylmal... |
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Potentiation of bradykinin-induced decrease of blood pressure in dogs by SO 14,551, the disulfide metabolite of captopril.
Jpn. J. Pharmacol. 32(5) , 934-7, (1982)
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Degradation of captopril in solutions compounded from tablets and standard powder.
Am. J. Hosp. Pharm. 51(9) , 1205-7, (1994)
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Electrochemical reduction of disulfides.
Meth. Enzymol. 143 , 257-64, (1987)
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