1,2-Distearoyl-sn-glycero-3-phosphoethanolamine
1,2-Distearoyl-sn-glycero-3-phosphoethanolamine structure
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Common Name | 1,2-Distearoyl-sn-glycero-3-phosphoethanolamine | ||
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| CAS Number | 1069-79-0 | Molecular Weight | 748.065 | |
| Density | 0.996 | Boiling Point | 760.2±70.0 °C at 760 mmHg | |
| Molecular Formula | C41H82NO8P | Melting Point | 172-173ºC | |
| MSDS | Chinese USA | Flash Point | 413.5±35.7 °C | |
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ICAM-1-Targeted, Lcn2 siRNA-Encapsulating Liposomes are Potent Anti-angiogenic Agents for Triple Negative Breast Cancer.
Theranostics 6 , 1-13, (2016) Lipocalin 2 (Lcn2) is a promising therapeutic target as well as a potential diagnostic biomarker for breast cancer. It has been previously shown to promote breast cancer progression by inducing the epithelial to mesenchymal transition in breast cancer cells a... |
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Topical drug delivery to retinal pigment epithelium with microfluidizer produced small liposomes.
Eur. J. Pharm. Sci. 62 , 23-32, (2014) Drug delivery from topically instilled eye drops to the posterior segment of the eye has long been one of the greatest challenges of ocular drug development. We developed methods of liposome preparation utilizing a microfluidizer to achieve adjustable nanopar... |
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A carbon nanotube-polymer composite for T-cell therapy.
Nat. Nanotechnol. 9(8) , 639-47, (2014) Clinical translation of cell therapies requires strategies that can manufacture cells efficiently and economically. One promising way to reproducibly expand T cells for cancer therapy is by attaching the stimuli for T cells onto artificial substrates with hig... |
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Optimization of Lipid Nanoparticle Formulations for mRNA Delivery in Vivo with Fractional Factorial and Definitive Screening Designs.
Nano Lett. 15 , 7300-6, (2015) Intracellular delivery of messenger RNA (mRNA) has the potential to induce protein production for many therapeutic applications. Although lipid nanoparticles have shown considerable promise for the delivery of small interfering RNAs (siRNA), their utility as ... |
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Generation, characterization and in vivo biological activity of two distinct monoclonal anti-PEG IgMs.
Toxicol. Appl. Pharmacol. 277(1) , 30-8, (2014) PEGylation, the attachment of polyethylene glycol (PEG) to nanocarriers and proteins, is a widely accepted approach to improving the in vivo efficacy of the non-PEGylated products. However, both PEGylated liposomes and PEGylated proteins reportedly trigger th... |
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Influence of phospholipid composition on cationic emulsions/DNA complexes: physicochemical properties, cytotoxicity, and transfection on Hep G2 cells.
Int. J. Nanomedicine 6 , 2213-20, (2011) Cationic nanoemulsions have been recently considered as potential delivery systems for nucleic acids. This study reports the influence of phospholipids on the properties of cationic nanoemulsions/DNA plasmid complexes.Nanoemulsions composed of medium-chain tr... |
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Effect of liposomes on rheological and syringeability properties of hyaluronic acid hydrogels intended for local injection of drugs.
Int. J. Pharm. 487 , 187-96, (2015) The aim of this work was to thoroughly study the effect of liposomes on the rheological and the syringeability properties of hyaluronic acid (HA) hydrogels intended for the local administration of drugs by injection. Whatever the characteristics of the liposo... |
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Target selective micelles for bombesin receptors incorporating Au(III)-dithiocarbamato complexes.
Int. J. Pharm. 473(1-2) , 194-202, (2014) Pure sterically stabilized micelles (SSM) of DSPE-PEG2000, and sterically stabilized mixed micelles (SSMM) containing PC or DOPC phospholipids (5, 10 or 20% mol/mol with respect to DSPE-PEG2000) are developed as delivery systems for the gold based cytotoxic d... |
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Characterization of 9-nitrocamptothecin-in-cyclodextrin-in-liposomes modified with transferrin for the treating of tumor.
Int. J. Pharm. 490 , 219-28, (2015) Encapsulation of hydrophobic drugs in the form of drug-cyclodextrin (CD) complex in liposomes has been applied as a novel strategy to combine the relative advantages of CDs and liposomes into one system, naming drug-in-CD-in-liposome (DCL). In the present stu... |
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Physicochemical characterization of asulacrine towards the development of an anticancer liposomal formulation via active drug loading: stability, solubility, lipophilicity and ionization.
Int. J. Pharm. 473(1-2) , 528-35, (2014) To facilitate the development of a liposomal formulation for cancer therapy, the physicochemical properties of asulacrine (ASL), an anticancer drug candidate, were characterized. Nano-liposomes were prepared by thin-film hydration in conjugation with active d... |